Association of <i>TNFA</i> –308 G/A and <i>TNFRI</i> +36 A/G Gene Polymorphisms with Glaucoma

Vol. 42, No. 3, 2009

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Original Paper

Association of TNFA -308 G/A and TNFRI +36 A/G Gene Polymorphisms with Glaucoma
Mohammad Reza Razeghinejad^a, Feisal Rahat^a, Eskandar Kamali-Sarvestani^{b, c}

^aDepartment of Ophthalmology,
^bDepartment of Immunology and
^cAutoimmune Diseases Research Center, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran

Address of Corresponding Author

Ophthalmic Res 2009;42:118-124 (DOI: 10.1159/000226108)

Key Words

Glaucoma
Tumor necrosis factor
Polymorphism

Abstract

Objective: TNF- alpha is one of the most important factors recognized in the pathogenesis of open-angle glaucoma. Therefore, the association of single nucleotide polymorphisms in the TNFRI gene and the promoter region of the TNFA gene with glaucoma susceptibility was investigated in the present study. Method: In total, 223 patients with glaucoma and 202 unrelated controls were genotyped by allele-specific oligonucleotide PCR and PCR- restriction fragment length polymorphism to determine TNFA -308 G/A and TNFRI +36 A/G polymorphisms, respectively. Results: In contrast to TNFRI polymorphisms, the genotypes of TNFA -308 G/A polymorphisms showed a significant difference between patients and controls (p = 0.0025). Of interest, the distribution of TNFA genotypes was significantly different between patients with primary open-angle glaucoma (p = 0.001) or pseudoexfoliative glaucoma (p = 0.001) and controls, while no difference was found when chronic angle-closure glaucoma patients were compared to controls (p = 0.72). Conclusion: In line with studies showing the role of TNF- alpha in open-angle glaucoma, the results of the present study showed that inheritance of the high producer TNFA -308 A allele might be a susceptibility factor for the development of open-angle glaucoma.

Author Contacts

Prof. Eskandar Kamali-Sarvestani
Department of Immunology, Shiraz Medical School
Shiraz University of Medical Sciences
71345-1798 Shiraz (Iran)
Tel./Fax +98 711 230 4069, E-Mail immunol2@sums.ac.ir

Article Information

Received: November 18, 2008
Accepted after revision: January 28, 2009
Published online: June 24, 2009
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 3, Number of References : 29

Medline Abstract (ID 19556827)

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