Case Report · Description de cas · Fallbericht

Orbital Tumor in Acute Myeloid Leukemia Associated with Karyotype 46,XX,t(8;21)(q22;q22): A Case Report
Maki Tanigawa^a, Yasuo Tsuda^a, Tsugio Amemiya^a, Kazuhiko Yamada^b, Masahiko Nakayama^b, Yoshiro Tsuji^b

Departments of
^aOphthalmology and
^bPediatrics, Nagasaki University School of Medicine, Nagasaki, Japan

Address of Corresponding Author

Ophthalmologica 1998;212:202-205 (DOI: 10.1159/000027279)

  Key Words

• Orbital tumor
• Acute myeloid leukemia
• Chromosomal translocation t(8;21)

  Abstract

Orbital tumor formation in acute myeloid leukemia (AML) is rare as an initial symptom. Furthermore, orbital granulocytic sarcoma (myeloid sarcoma) in pediatric patients is uncommon. We describe a 5-year-old Japanese girl with a left orbital mass as an initial symptom of AML, the mass revealed by computed tomography. Periperal blood and bone marrow pictures and a chromosomal analysis disclosing 46,XX,t(8;21)(q22;q22) showed AML (M2 according to the French-American-British classification). She was treated with antileukemic chemotherapy systemically. Three weeks after the initiation of chemotherapy, the orbital tumor regressed markedly. AML as an initial symptom of the orbital mass should be fully considered in a differential diagnosis, even in the absence of typical leukemic symptoms, and chromosomal analysis and immunophenotypical analysis may explain the pathogenesis of the extramedullary leukemic tumor.

  Author Contacts

Maki Tanigawa, MD
Department of Ophthalmology
Nagasaki University School of Medicine
1-7-1 Sakamoto, Nagasaki 852 (Japan)
Tel. 81 (95) 849 7345, Fax 81 (95) 849 7347

  Article Information

Received: Received: March 6, 1997
Accepted: May 21, 1997
Number of Print Pages : 4
Number of Figures : 6, Number of Tables : 0, Number of References : 27