Born Small for Gestational Age: Increased Risk of Type 2 Diabetes, Hypertension and Hyperlipidaemia in Adulthood

Vol. 59, Suppl. 1, 2003

Free Abstract Article (Fulltext) Article (PDF 178 KB)

Proceedings of the 13th Novo Nordisk Symposium on Growth Hormone and Endocrinology
Budapest, April 12-13, 2002
and Proceedings of the SGA/IUGR Satellite Symposium
Budapest, April 11, 2002
Editors: M.B. Ranke, Tübingen; J.S. Christiansen, Aarhus

SGA/IUGR Satellite Symposium

Born Small for Gestational Age: Increased Risk of Type 2 Diabetes, Hypertension and Hyperlipidaemia in Adulthood
Delphine Jaquet, Paul Czernichow

INSERM Unité 457, Hôpital Robert Debré, Paris, France

Address of Corresponding Author

Horm Res 2003;59 (Suppl. 1):131-137 (DOI: 10.1159/000067848)

Key Words

Reduced fetal growth
Insulin-resistance
Adipose tissue
Genotype/Phenotype interaction

Abstract

The metabolic and cardiovascular complications associated with reduced fetal growth have been identified in the past 10 years. These include cardiovascular disease and the insulin resistance syndrome, comprising dyslipidaemia and impaired glucose tolerance or type 2 diabetes, and they appear to result from the initial development of insulin resistance. Although the mechanism underlying the development of insulin resistance associated with reduced fetal growth remains unclear, there is some evidence that adipose tissue plays a key role. Over the past decade, several hypotheses have been proposed to explain this unexpected association. Each points to either a detrimental fetal environment, genetic susceptibility or an interaction between the two. Although yet to be confirmed, the hypothesis suggesting that the association could be the consequence of genetic-environmental interactions is at present the most attractive.

Author Contacts

Prof. Paul Czernichow
INSERM Unité 457
Hôpital Robert Debré
F-75019 Paris (France)
Tel. +33 1 4003 2360, Fax +33 1 4003 2429, E-Mail paul.czernichow@rdb.ap-hop-paris.fr

Article Information

Number of Figures : 5, Number of Tables : 0, Number of References : 47

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