Case Report

Intravitreal r-TPA and Gas Injection in Traumatic Submacular Hemorrhage
Detlef Holland^a, Burkhard Wiechens<sup>b

a</sup>Department of Ophthalmology, Christian Albrechts University Kiel, Kiel, and
^bDepartment of Ophthalmology, Klinikum Hannover, Hannover, Germany

Address of Corresponding Author

Ophthalmologica 2004;218:64-69 (DOI: 10.1159/000074569)

  Key Words

• Choroidal rupture
• Intravitreal gas
• Submacular hemorrhage
• Recombinant tissue plasminogen activator
• Ocular trauma

  Abstract

Aim: To present the technique and efficiency of intravitreal recombinant tissue plasminogen activator (r-TPA) and gas injection in acute submacular hemorrhage (SMH) due to traumatic choroidal rupture. Patients and Methods: 0.4 ml of sulfur hexafluoride was injected into the vitreous cavity in 2 patients with SMH due to traumatic choroidal rupture. In 1 patient gas injection was combined with 50 µg r-TPA. Both patients were closely followed. Results: Preoperative visual acuity was 20/125 in one eye and 20/100 in the other. At the end of the follow-up, visual acuity had improved to 20/32 in both eyes. Conclusion: r-TPA and gas injection into the vitreous body may be an efficient therapy in patients with submacular hemorrhage due to choroidal rupture.

Copyright © 2004 S. Karger AG, Basel

  Author Contacts

Detlef Holland, MD
Hegewischstrasse 2
DE-24105 Kiel (Germany)
Tel. +49 431 5972367, Fax +49 431 5972422
E-Mail dholland@ophthalmol.uni-kiel.de

  Article Information

Minor parts of this paper were presented at the annual meeting of the Deutsche Ophthalmologische Gesellschaft, Berlin, September 21-24, 2000. The authors have no proprietary interests.

Received: January 3, 2002
Accepted after revision: May 26, 2003
Number of Print Pages : 6
Number of Figures : 5, Number of Tables : 0, Number of References : 18