In-Depth Topic Review

Cellular Lipid Metabolism and the Role of Lipids in Progressive Renal Disease
Christine K. Abrass

Department of Medicine, University of Washington School of Medicine, Seattle, Wash., USA

Address of Corresponding Author

Am J Nephrol 2004;24:46-53 (DOI: 10.1159/000075925)

  Key Words

• Dyslipidemia
• Mesangial cells
• Cholesterol
• Chronic kidney disease, lipid metabolism
• Glomerulosclerosis
• Lipids

  Abstract

Dyslipidemia contributes to the rate of progression of atherosclerosis and chronic kidney disease. Also, chronic kidney disease leads to the development of secondary abnormalities in lipid metabolism that contribute to increased cardiovascular morbidity and mortality. This review presents the mechanisms that underlie this risk. The mechanisms of normal cellular lipid metabolism and the abnormalities that develop in association with inflammation are reviewed. There is a special emphasis on foam cells in the kidney and on lipid-mediated changes in intrinsic kidney cells that lead to glomerulosclerosis and interstitial fibrosis. Correlates to studies performed in whole animals and humans are included.

Copyright © 2004 S. Karger AG, Basel

  Author Contacts

Christine K. Abrass, MD
VAPSHCS, 1660 S. Columbian Way
Seattle, WA 98108 (USA)
Tel. +1 206 764 2002, Fax +1 206 764 2022
E-Mail cabrass@u.washington.edu

  Article Information

Received: October 13, 2003
Accepted: October 23, 2003
Published online: December 30, 2003
Number of Print Pages : 8
Number of Figures : 1, Number of Tables : 0, Number of References : 75