The Insulin-Like Growth Factor System and Markers of Inflammation in Adult Patients with Inflammatory Bowel Disease

Vol. 64, No. 1, 2005

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Original Paper

The Insulin-Like Growth Factor System and Markers of Inflammation in Adult Patients with Inflammatory Bowel Disease
M. Eivindson^{a, c}, J.N. Nielsen^b, H. Grønbæk^c, A. Flyvbjerg^d, H. Hey^c

Departments of
^aMedicine and
^bClinical Biochemistry, Vejle Hospital, Vejle;
^cMedical Department V, and
^dMedical Research Laboratories, Aarhus University Hospital, Aarhus, Denmark

Address of Corresponding Author

Horm Res 2005;64:9-15 (DOI: 10.1159/000087190)

Key Words

IGF-I
IGF-II
IGFBP-3
Inflammatory bowel disease
Crohn's disease
Ulcerative colitis
Interleukin-6

Abstract

Background and Objectives:Catabolism and growth impairment are well-known complications of inflammatory bowel disease (IBD). Recent studies have demonstrated significant changes in the IGF system in IBD patients. The aim of the present study was to investigate correlations between the IGF system and markers of inflammation in IBD. Methods:A cross-sectional study comprising 99 IBD patients (Crohn's disease (CD, n = 50) and ulcerative colitis (UC, n = 49)). Correlations between markers of inflammation and IGF-I, IGF-II and IGFBP-3 were examined in CD and UC patients in remission and relapse. The patients were clinically scored using Crohn's Disease Activity Index (CDAI) for CD patients and Activity Index (AI) for UC patients. Results: In the UC group we found correlations between IGF-I and CRP (r_s = Spearman's rho) (r_s = -0.40, p < 0.01) and albumin (r_s = 0.46, p < 0.001), IGFBP-3 and albumin (r_s = 0.36, p < 0.01) and AI score (r_s = -0.31, p < 0.05). IGF-II correlated with CRP (r_s = -0.42, p < 0.01), IL-6 (r_s = -0.65, p < 0.001), albumin (r_s = 0.41, p < 0.01), AI score (r_s = -0.30, p < 0.05) and orosomucoid (r_s = -0.47, p < 0.001). In the CD group we found correlations between IGF-I and CRP (r_s = -0.40, p < 0.05), and albumin (r_s = -0.46, p < 0.01), IGFBP-3 and albumin (r = 0.36, p < 0.01). IGF-II correlated with IL-6 (r_s = -0.65, p < 0.001), albumin (r_s = 0.41, p < 0.01), CDAI score (r_s = -0.30, p < 0.05) and orosomucoid (r_s = -0.47, p < 0.001). Conclusions: IGF-I, IGF-II and IGFBP-3 are correlated to albumin and IGF-I and IGF-II are correlated to CRP in IBD patients. Further, IGF-II is correlated to IL-6 in IBD patients. This may suggest a correlation between inflammation and the IGF system with involvement in muscle and bone catabolism in IBD.

Author Contacts

Dr. Martin Eivindson
Department of Medicine, Vejle Hospital
DK-7900 Vejle (Denmark)
Tel. +45 4041 2662, Fax +45 8949 2740
E-Mail DocMartin@dadlnet.dk

Article Information

Received: November 9, 2004
Accepted: May 18, 2005
Published online: July 25, 2005
Number of Print Pages : 7
Number of Figures : 0, Number of Tables : 5, Number of References : 36

Medline Abstract (ID 16088202)

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