Address of Corresponding Author

Ophthalmologica 2005;219:379-385 (DOI: 10.1159/000088382)

  Key Words

• Optical coherence tomography
• Retinal nerve fiber layer thickness
• Retinal thickness

  Abstract

Purpose: To detect early diabetic damage in type 2 diabetes mellitus patients with no diabetic retinopathy (NDR) using optical coherence tomography (OCT) and to evaluate OCT as a clinical test. Methods: Thirty-two patients with NDR (n = 32) were enrolled. We examined retinal and retinal nerve fiber layer (RNFL) thickness using OCT. Two healthy normal populations were also enrolled for the retinal thickness (n = 48) and RNFL thickness (n = 34). Both OCT measurements were obtained in four areas (temporal, superior, nasal and inferior). The receiver operator characteristic (ROC) curve was generated to evaluate the predictor variables. Results: Comparing the normal and NDR eyes, retinal thickness significantly increased (p = 0.03) and RNFL thickness significantly decreased (p = 0.02) in the superior areas. The area under the ROC curve was 0.65 for the superior retinal thickness and 0.63 for the superior RNFL thickness. Conclusions: Both OCT measurements can detect early retinal damage in NDR patients.

Copyright © 2005 S. Karger AG, Basel

  Author Contacts

Masahiko Sugimoto
Department of Ophthalmology, School of Medicine
Mie University, 2-174 Edobashi
Tsu, 514-8507 (Japan)
Tel. +81 59 231 5027, Fax +81 59 231 3036, E-Mail sugmochi@aqua.ocn.ne.jp

  Article Information

Received: September 3, 2004
Accepted after revision: February 11, 2005
Number of Print Pages : 7
Number of Figures : 3, Number of Tables : 1, Number of References : 45