Serum Paraoxonase 1 Activity and Lipid Peroxidation Levels in Patients with Age-Related Macular Degeneration

Vol. 220, No. 1, 2006

Free Abstract Article (Fulltext) Article (PDF 137 KB)

Original Paper

Serum Paraoxonase 1 Activity and Lipid Peroxidation Levels in Patients with Age-Related Macular Degeneration
Gulden Baskol^a, Sarper Karakucuk^b, Ayse Ozturk Oner^b, Mevlut Baskol^c, Derya Kocer^a, Ertugrul Mirza^b, Recep Saraymen^a, Muzaffer Üstdal^a

Departments of
^aBiochemistry and Clinical Biochemistry,
^bOphthalmology and
^cInternal Medicine, Medical Faculty, Erciyes University, Kayseri, Turkey

Address of Corresponding Author

Ophthalmologica 2006;220:12-16 (DOI: 10.1159/000089269)

Key Words

Age-related macular degeneration
Paraoxonase 1
Malondialdehyde

Abstract

Our objective was to investigate antioxidant paraoxonase 1 (PON1) activity together with malondialdehyde (MDA) levels to evaluate oxidative stress in patients with age-related macular degeneration (AMD), an important cause of blindness in the elderly population. Serum PON1 activity and MDA levels were analyzed in 37 patients with AMD and compared with 29 healthy controls using a spectrophotometric method. Serum MDA levels were significantly higher in the patient group (2.76 ± 1.28 nmol/ml) than controls (1.00 ± 0.36 nmol/ml; p < 0.001), whereas PON1 activity was lower in the patient group (132.27 ± 63.39 U/l) than controls (312.13 ± 136.23 U/l; p < 0.001). There was a negative correlation between MDA and PON1 levels (r = -0.470, p < 0.001). We conclude that the observed increase in MDA levels may be related to decreased PON1 activity; the present data also demonstrated that an obvious negative correlation between PON1 activity and MDA levels exists in patients with AMD. PON1 is also an antioxidant agent, therefore effective antioxidant therapy to inhibit lipid peroxidation is necessary and agents to increase PON1 activity may be a therapeutic option in AMD.

Author Contacts

Dr. Gülden Baskol
Erciyes University, Medical Faculty
Department of Biochemistry and Clinical Biochemistry
TR-38039 Kayseri (Turkey)
Tel. +90 352 4374937, ext. 23289, Fax +90 352 4375565, E-Mail gbaskol@yahoo.com

Article Information

Received: December 2, 2004
Accepted after revision: March 11, 2005
Number of Print Pages : 5
Number of Figures : 3, Number of Tables : 1, Number of References : 47

Medline Abstract (ID 16374043)

Download Citation

Cited In

For non-native English speakers and international authors who would like assistance with their writing before submission, we suggest American Journal Experts for their scientific editing service.