Clamp Techniques in Paediatrics: What Have We Learned?

Vol. 64, Suppl. 3, 2005

Free Abstract Article (Fulltext) Article (PDF 197 KB)

Methods to Determine Insulin Sensitivity in Clinical Practice. Growth Hormone and Cognition.
Editor(s): Ranke, M.B. (Tübingen), Vance, M.L. (Charlottesville, Va.)

Insulin Sensitivity: Methods

Clamp Techniques in Paediatrics: What Have We Learned?
Silva A. Arslanian

Children's Hospital of Pittsburgh, Weight Management and Wellness Center, and Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Pittsburgh, Pa., USA

Address of Corresponding Author

Horm Res 2005;64 (Suppl. 3):16-24 (DOI: 10.1159/000089313)

Key Words

Insulin
Obesity
Type 2 diabetes mellitus
Children
Adolescence
Insulin resistance

Abstract

The marked increase in conditions associated with insulin resistance in youth, including obesity, polycystic ovary syndrome, type 2 diabetes mellitus etc., has prompted the need to assess insulin sensitivity in this age group. Even though insulin resistance plays an important role in disorders of glucose metabolism and other pathological conditions, both insulin sensitivity and insulin secretion should be determined for a comprehensive evaluation of glucose homeostasis disorders. Insulin sensitivity and secretion are intricately coupled with a delicate feedback mechanism governing their relationship. This article will delineate our paediatric experience with the clamp technique, the hyperinsulinaemic-euglycaemic clamp in assessing in vivo insulin sensitivity, and the hyperglycaemic clamp in assessing insulin secretion.

Author Contacts

Prof. Silva A. Arslanian
Division of Endocrinology, Children's Hospital of Pittsburgh
3705 Fifth Avenue at DeSoto Street
Pittsburgh, PA 15213 (USA)
Tel. +1 412 692 6565, Fax +1 412 692 5834, E-Mail Silva.Arslanian@chp.edu

Article Information

Published online: January 20, 2006
Number of Print Pages : 9
Number of Figures : 3, Number of Tables : 0, Number of References : 61

Medline Abstract (ID 16439840)

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