Cystatin C – A Marker for Assessment of the Glomerular Filtration Rate in Patients with Cisplatin Chemotherapy

Vol. 29, No. 1, 2006

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Original Paper

Cystatin C - A Marker for Assessment of the Glomerular Filtration Rate in Patients with Cisplatin Chemotherapy
P. Benöhr^a, A. Grenz^b, J.T. Hartmann^c, G.A. Müller^a, S. Blaschke^a

^aDepartment of Nephrology and Rheumatology, University of Göttingen, Göttingen;
^bDepartment of Pharmacology and Toxicology, University of Tübingen, Tübingen, and
^cMedical Center II, Department of Hematology and Oncology, Immunology and Rheumatology, Tübingen, Germany

Address of Corresponding Author

Kidney Blood Press Res 2006;29:32-35 (DOI: 10.1159/000092485)

Key Words

Cystatin C
Creatinine
Cisplatin
Chemotherapy
Glomerular filtration rate
Inulin clearance

Abstract

Background: Cystatin C has recently been proposed as an ideal marker for glomerular filtration rate (GFR). In this study, cystatin C serum levels were evaluated in comparison to serum creatinine concentrations and inulin clearances in patients with normal kidney function receiving cisplatin-based chemotherapy to assess the validity of cystatin C as an alternative endogenous marker of GFR. Methods: Blood samples for the assessment of cystatin C, creatinine and inulin clearances were collected in patients before and after application of cisplatin in a clinical trial. Overall, 41 patients were included in the study, 35 of them were eligible receiving cisplatin in two different cisplatin-based chemotherapy schedules. Results: A 21% increase of cystatin C serum levels was demonstrated in the placebo group after application of cisplatin. Analysis of inulin clearances revealed a 23% loss of inulin clearance in patients of the placebo arm. In contrast, significant changes could not be detected by analysis of serum creatinine levels. Conclusions: Cystatin C represents a more sensitive clinical marker than serum creatinine for the early assessment of GFR damage caused by cisplatin. Changes in cystatin C serum concentrations correlate well to GFR decrease as measured by inulin clearance.

Author Contacts

Peter Benöhr, MD
Department of Nephrology and Rheumatology
Georg August University Göttingen, Robert-Koch Strasse 40
DE-37075 Göttingen (Germany)
Tel. +49 551 39 8509, Fax +49 551 39 8507, E-Mail pbenoeh@gwdg.de

Article Information

Received: September 14, 2005
Accepted: January 2, 2006
Published online: March 31, 2006
Number of Print Pages : 4
Number of Figures : 1, Number of Tables : 1, Number of References : 14

Medline Abstract (ID 16582575)

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