Is Osteoarthritis an Infection-Associated Disease and a Target for Chemotherapy?

Vol. 53, No. 1, 2007

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Is Osteoarthritis an Infection-Associated Disease and a Target for Chemotherapy?
Alexander Rozin

B. Shine Department of Rheumatology, Rambam Medical Center, and B. Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

Address of Corresponding Author

Chemotherapy 2007;53:1-9 (DOI: 10.1159/000098243)

Key Words

Osteoarthritis
Cotrimoxazole
Recurrent urinary tract infection

Abstract

The treatment of osteoarthritis (OA) continues to be a challenge, and current treatment modalities are disappointing. New approaches in therapy may be developed as a result of evidence of the involvement of inflammatory cytokines in the progression of OA. Cotrimoxazole (sulfamethoxazole/trimethoprim) was noted to have anti-inflammatory properties and has been used in the therapy of several autoimmune diseases. Analyzing our own and world experience, we propose that OA and degenerative joint and spine disease might be infection-associated diseases and a target for sulfamethoxazole/trimethoprim therapy.

Author Contacts

Dr. Alexander Rozin
Department of Rheumatology
Rambam Medical Center, POB 9602
Haifa 31096 (Israel)
Tel. +972 4 854 2268, Fax +972 4 854 2985, E-Mail a_rozin@ambam.health.gov.il

Article Information

Received: October 25, 2004
Accepted after revision: December 13, 2005
Published online: December 28, 2006
Number of Print Pages : 9
Number of Figures : 1, Number of Tables : 3, Number of References : 64

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