Intestinal Mucosal Damage and Repair
5th Eisai Biwako Symposium
November 19-20, 1999, Lake Biwa, Shiga, Japan
Guest Editor: Tadao Bamba, Shiga

New Aspects and Mucosal Repair

Helicobacter pylori Infection Increases Mucosal Permeability of the Stomach and Intestine
Yoshihiro Fukuda^a, Hiroko Bamba^a, Masanori Okui^a, Kazutami Tamura^a, Noritoshi Tanida^a, Masamichi Satomi^a, Takashi Shimoyama^a, Takashi Nishigami<sup>b

a</sup>Departments of Internal Medicine 4 and
^bPathology 2, Hyogo College of Medicine, Hyogo, Japan

Address of Corresponding Author

Digestion 2001;63:93-96 (DOI: 10.1159/000051918)

  Key Words

• Helicobacter pylori
• Mucosal permeability
• Sucrose
• Gastritis

  Abstract

It is important to study the effect of Helicobacter pylori infection on the permeability of the intestine. Permeability was evaluated by oral sucrose tolerance test using sucrose 25 g in 200 ml of water. Existence of H. pylori itself was associated with increased permeability of sucrose. Also, the permeability of sucrose increased as polymorphonuclear and lymphocyte infiltration increased. The increase of mucosal permeability suggests that antigens like protein penetrate into the body and result in systemic reactions. Thus, it is important to study the implication of increased permeability in relation not only to gastric diseases but also certain systemic diseases.

Copyright © 2001 S. Karger AG, Basel

  Author Contacts

Y. Fukuda, MD
Department of Internal Medicine 4, Hyogo College of Medicine
1-1, Mukogawa-cho, Nishinomiya-city
Hyogo, 663-8131 (Japan)
Fax +81 798 45 6664, E-Mail cdhpyf@hyo-med.ac.jp

  Article Information

Number of Print Pages : 4
Number of Figures : 4, Number of Tables : 0, Number of References : 30