Enhancement of IgE Production in B Cells by Neutrophils via Galectin-3 in IgE-Associated Atopic Eczema/Dermatitis Syndrome

Vol. 128, No. 2, 2002

Free Abstract Article (Fulltext) Article (PDF 53 KB)

Short Communication

Enhancement of IgE Production in B Cells by Neutrophils via Galectin-3 in IgE-Associated Atopic Eczema/Dermatitis Syndrome
Hajime Kimata

Department of Allergy, Unitika Central Hospital, Uji-City, Japan

Address of Corresponding Author

Int Arch Allergy Immunol 2002;128:168-170 (DOI: 10.1159/000059408)

Key Words

Atopic eczema/dermatitis syndrome
Galectin-3
IgE production
Neutrophils

Abstract

Spontaneous IgE production by B cells from patients with IgE-associated atopic eczema/dermatitis syndrome (AEDS) is enhanced by polymorphonuclear leukocytes (PMN) from patients with AEDS, but not by PMN from non-atopic controls. The enhancement is abolished by preincubation of PMN with lactose, but not with glucose. Anti-galectin-3 serum, but not control rabbit serum, blocked the enhancement. These results indicate that AEDS PMN can enhance IgE production via galectin-3.

Author Contacts

Correspondence to: Dr. Hajime Kimata
Department of Allergy, Unitika Central Hospital
24-1, Umonji, Uji
Uji-City, Kyoto Prefecture 611-0021 (Japan)
Tel. +81 774 25 2500, Fax +81 774 25 2353, E-Mail unitikah@m12.alpha-net.ne.jp

Article Information

Received: Received: November 16, 2001
Accepted after revision: February 14, 2002
Number of Print Pages : 3
Number of Figures : 0, Number of Tables : 1, Number of References : 7

Medline Abstract (ID 12065918)

Download Citation

This journal is part of the fourth subject package of the Karger

Journal Archive Collection

Information on packages (PDF)
Free sample issues

For non-native English speakers and international authors who would like assistance with their writing before submission, we suggest American Journal Experts for their scientific editing service.