Original Paper · Travail original · Originalarbeit

Ocular Concentrations of Mitomycin C Using Different Delivery Devices
Holger Mietz^a, Michael Diestelhorst^a, A. F. E. Rump^b, Michael Theisohn^b, W. Klaus^b, Günter K. Krieglstein<sup>a

a</sup>Department of Ophthalmology and
^bInstitute of Pharmacology, University of Cologne, Germany

Address of Corresponding Author

Ophthalmologica 1998;212:37-42 (DOI: 10.1159/000027257)

  Key Words

• Glaucoma
• Mitomycin C
• HPLC
• Rabbit
• Toxicity

  Abstract

Hypotony and its sequelae are a frequent complication of trabeculectomies performed with mitomycin C (MMC), possibly related to intraocular toxicity of the substance. In an animal model with rabbits, we used different devices for the application of MMC and measured extra- and intraocular concentrations by HPLC. In addition, the concentrations of MMC remaining in the devices were determined. The devices were (1) a regular surgical sponge, (2) a scleral shield, (3) a presoaked soft contact lens, (4) a soft contact lens with MMC application, and (5) subconjunctival injection. Ocular concentrations of MMC were similar within the first 4 groups and were highest in the last. The measurements suggest that MMC penetrates intraocularly regardless of the device used. The variability of remaining MMC concentrations in the devices was lowest in the soft contact lenses suggesting an improved delivery system compared to the usually used surgical sponges.

  Author Contacts

H. Mietz
Department of Ophthalmology
University of Cologne
D-50924 Köln (Germany)
Fax ++49 221 478 4347

  Article Information

Received: Received: August 8, 1996
Accepted: October 22, 1996
Number of Print Pages : 6
Number of Figures : 3, Number of Tables : 2, Number of References : 20