Mucosal Immunity in HIV Infection
Proceedings of the International Symposium
June 6-7, 1997, Berlin
Guest Editors: Reiner Ullrich, Berlin; Wolfgang Schmidt, Berlin; Ernst-Otto Riecken, Berlin; Martin Zeitz, Homburg/Saar

Paper

Chemoattractant Factors and the Control of Human Immunodeficiency Virus Replication
Michael Baier, Norbert Bannert, Albrecht Werner, Henric S. Adler, Ahlert Otteken, Brigitte Beer, Steve Norley, Reinhard Kurth

Paul Ehrlich Institute, Langen, Germany

Address of Corresponding Author

Pathobiology 1998;66:128-130 (DOI: 10.1159/000028008)

  Key Words

• Chemokines
• Interleukin-16
• CD8(+) T-cell-associated antiviral factors

  Abstract

Factors secreted by CD8(+) T cells have been described to suppress immunodeficiency virus replication. The research efforts to identify these factors led to the proposal of some candidate proteins as being responsible for the antiviral effects. Chemokines and IL-16 are secreted by CD8(+) T cells and inhibit HIV replication through different mechanisms. However, their antiviral properties cannot fully explain the inhibitory activities found in cell culture supernatants from CD8(+) T cells.

  Author Contacts

Dr. Michael Baier
Paul-Ehrlich-Institut
Paul-Ehrlich-Strasse 51-59
D-63225 Langen (Germany)
E-Mail m.baier@em.uni-frankfurt.de

  Article Information

Number of Print Pages : 3
Number of Figures : 0, Number of Tables : 0, Number of References : 21