Address of Corresponding Author

Exog Dermatol 2003;2:301-305 (DOI: 10.1159/000081567)

  Key Words

• Irritant contact dermatitis
• Atopiclair
• MAS063D
• Emollient
• Itching

  Abstract

Background: Irritant contact dermatitis (ICD) is commonly treated with topical corticosteroids. MAS063D (‘Atopiclair’) is a nonsteroidal effective in atopic dermatitis. Objective: To determine the efficacy of a topical agent, MAS063D, in managing ICD. Methods: Two sites of ICD were created using sodium lauryl sulfate (SLS) in 20 volunteers; MAS063D was then applied to one and a vehicle-only control to the other. Measurements were taken at baseline, 24, 48 and 72 h. Results: The objective measurements of blood flow volume (BFV), skin color (a*) and transepidermal water loss (TEWL) all showed statistically significant benefits of MAS063D over the vehicle-only control. BFV and a* were significantly better at all time points (p = 0.046, p = 0.045, respectively, at 72 h) and TEWL at 48 and 72 h (p = 0.02 at 72 h). Conclusion: MAS063D demonstrated benefits over vehicle in three clinically meaningful outcomes of SLS-induced ICD.

Copyright © 2003 S. Karger AG, Basel

  Author Contacts

Hongbo Zhai, MD
Department of Dermatology, University of California
School of Medicine, 90 Medical Center Way, Surge 110, Box 0989
San Francisco, CA 94143–0989 (USA)
Tel. +1 415 514 1537, Fax +1 415 753 5304, E-Mail hongbo@itsa.ucsf.edu

  Article Information

Received: March 22, 2004
Accepted after revision: June 15, 2004
Number of Print Pages : 5
Number of Figures : 4, Number of Tables : 0, Number of References : 18