COX-2
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A New Target for Cancer Prevention and Treatment
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Recent insights of leading investigators
Numerous investigators have found increased levels of cyclooxygenase-2 (COX-2) in both pre-malignant and malignant tissues. Moreover, animals engineered to be COX-2 deficient or treated with a selective COX-2 inhibitor showed reduced tumor formation and growth.
The present book reviews these findings suggesting that COX-2 is a valid molecular target for the prevention and treatment of cancer. The first chapters are devoted to the epidemiology of nonsteroidal anti-inflammatory drugs (NSAIDs) and cancer, the pharmacology of COX-2 inhibitors and the regulation of COX-2 expression in human cancers. Besides, the book contains a series of chapters examining the link between COX-2 and cancer in specific organs (e.g. skin, breast, cervix, digestive tract, lung, etc.). Furthermore, several clinical trials assessing the potential of COX-2 inhibitors for preventing and treating cancer are described. The final chapter provides an up-to-date consideration of COX-independent targets of NSAIDs and related compounds in cancer prevention and treatment.
This state-of-the-art publication is recommended reading not only for medical and radiation oncologists, but also for pharmacologists, gastroenterologists and other subspecialists.
Progress in Experimental Tumor Research,
Vol. 37
ISSN: 0079-6263
e-ISSN: 1662-3916
COX-2
A New Target for Cancer Prevention and Treatment
Editor(s):
Dannenberg, A.J. (New York, N.Y.);
DuBois, R.N. (Nashville, Tenn.)
VIII + 292 p.,
32 fig.,
6 in color,
20 tab.,
hard cover,
2003
Status: available
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ISBN: 978-3-8055-7536-2
e-ISBN: 978-3-318-00940-8
Notes:
Spanish Translation: "COX-2" (Jarpyo Editores, Madrid 2003)
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