Title Index Book Series Non-serial Titles Book News Complement in Autoimmunity Editor(s):   Tsokos, G.C. (Silver Spring, Md.)  Online Access      Table of Contents / Fulltext / Pay Per View A vital approach to a key component of the innate immune system Complement protein expression and activation control central aspects of the normal B cell response. Imbalances in these processes invariably lead to autoimmune disease. Complement activation causes tissue damage in a number of ways and may by itself lead to autoimmune disease. Although the use of complement activation inhibitors in the treatment of complement-mediated tissue injury and disease is largely in pre-clinical trials, the expectations that they will be of significant clinical value are high. This volume contains a series of review articles that address the role of complement in the pathogenesis of autoimmune disease and the ensuing tissue damage. Topics include structural and functional aspects of the CD19/CD21/CD81 complex, role of the complement system in the expression of systemic lupus erythematosus (SLE) and antiphospholipid antibody syndrome. Also featured is the role of complement activation in ischemia/reperfusion and autoimmune disease injury. Finally, in-depth reviews about complement activation in the development of glomerulonephritis in autoimmune disease and the function of membrane-bound complement regulatory proteins in autoimmunity are presented. Students as well as basic and clinical researchers in immunology who wish to understand the role of complement in the pathogenesis of autoimmune disease will value this comprehensive and up-to-date publication. Current Directions in Autoimmunity,  Vol. 7 ISSN: 1422-2132 e-ISSN: 1662-2936 Complement in Autoimmunity  Editor(s):   Tsokos, G.C. (Silver Spring, Md.) VI + 206 p.,  21 fig.,  2 in color,  10 tab.,  hard cover,  2004 Status: available      CHF  EUR  USD        (Germany only)  (USA only)    List price  198.-  141.50  172.25    Prices subject to change  Order this title Print Edition Online Edition Order Information ISBN: 978-3-8055-7646-8 e-ISBN: 978-3-318-01024-4 Series Home Details & Prices  Order this title Print Edition Online Edition Order Information PDF Leaflet  Further Reading Immunology Biochemistry Cell Biology Genetics Hematology Infectious Diseases Nephrology Rheumatology Search in this book  © 2010 S. Karger AG, Basel