Non-A, Non-B Hepatitis Transmission in Chimpanzees: A Project of the Transfusion-Transmitted Viruses Study Group

Vol. 10, No. 1, 1978

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Paper

Non-A, Non-B Hepatitis Transmission in Chimpanzees: A Project of the Transfusion-Transmitted Viruses Study Group
Blaine Hollinger, Gary L. Gitnick, Richard D. Aach, Wolf Szmuness, James W. Mosley, Cladd E. Stevens, Robert L. Peters, John M. Weiner, Jochewed B. Werch, Jerrold J. Lander

Address of Corresponding Author

Intervirology 1978;10:60-68 (DOI: 10.1159/000148969)

Key Words

Non-A, non-B hepatitis
Chimpanzees
Transmission
Posttransfusion hepatitis

Summary

Experimental transmission of non-A, non-B hepatitis was apparently accomplished in 5 chimpanzees following inoculation with presumably infectious human sera. Administration of sera from implicated donors with normal alanine aminotransferase (ALT) values, as well as from those with abnormal ALT levels, resulted in the development of ALT abnormalities in the inoculated chimpanzees. Transmission from donors with normal ALT values implies that healthy carriers of non-A, non-B virus exist. Evidence is presented which indicates that a period of viremia precedes the clinical illness by at least 12 days.

Author Contacts

Address inquiries to: F. Blaine Hollinger, Department of Virology and Epidemiology, Baylor College of Medicine, Houston, TX 77030 (USA)

Article Information

Received: January 25, 1978
Published online: July 23, 2008
Number of Print Pages : 9

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