Prediction of Creatinine Clearance from Serum Creatinine

Vol. 16, No. 1, 1976

Free Abstract Article (PDF 2503 KB)

Paper

Prediction of Creatinine Clearance from Serum Creatinine
Donald W. Cockcroft, Henry Gault

Departments of Medicine, Queen Mary Veterans' Hospital, Montreal, Quebec, and Memorial University, St. John's, Newfoundland

Address of Corresponding Author

Nephron 1976;16:31-41 (DOI: 10.1159/000180580)

Key Words

Serum creatinine
Creatinine clearance
Creatinine excretion
Renal function
Age

Abstract

A formula has been developed to predict creatinine clearance (C_cr) from serum creatinine (S_cr) in adult males: Ccr = (140 - age) (wt kg)/72 × S_cr(mg/100ml) (15% less in females). Derivation included the relationship found between age and 24-hour creatinine excretion/kg in 249 patients aged 18-92. Values for C_cr were predicted by this formula and four other methods and the results compared with the means of two 24-hour C_cr's measured in 236 patients. The above formula gave a correlation coefficient between predicted and mean measured Ccr·s of 0.83; on average, the difference between predicted and mean measured values was no greater than that between paired clearances. Factors for age and body weight must be included for reasonable prediction.

Author Contacts

M.H. Gault, MD, Memorial University Research Unit, The General Hospital, St. John's, Newfoundland A1 A 1E5 (Canada)

Article Information

Received: November 29, 1974
Accepted: January 28, 1975
Published online: November 28, 2008
Number of Print Pages : 11

This journal is part of the third subject package of the Karger

Journal Archive Collection

Information on packages (PDF)
Free sample issues

For non-native English speakers and international authors who would like assistance with their writing before submission, we suggest American Journal Experts for their scientific editing service.