Lysine in Treatment of Hyperornithinemia

Vol. 22, No. 1-3, 1978

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Original Paper

Lysine in Treatment of Hyperornithinemia
C. Giordano, N.G. De Santo, M. Pluvio, R. Santinelli, G. Stoppoloni

Chair of Nephrology and Institute of Pediatrics, University of Naples, Naples

Address of Corresponding Author

Nephron 1978;22:97-106 (DOI: 10.1159/000181428)

Key Words

Lysine load
Hyperornithinemia
Nitrogen balance
Gyrate atrophy of choroid and retina

Abstract

A metabolic study in a case of hyperornithinemia with gyrate atrophy of choroid and retina is presented. It is demonstrated that the lysine-ornithine antagonism is a physiological, safe, easy to handle therapeutic tool in hyperornithinemia. A lysine load was invariably associated with a reduction of plasma ornithine concentration. This happened at any level of protein intake. It was also shown that diets containing a low protein intake are invariably associated with negative nitrogen balance.

Author Contacts

Prof. Carmelo Giordano, Cattedra di Nefrologia Medica, Università di Napoli, Piazza Miraglia, Policlinico, I-80138 Napoli (Italy)

Article Information

Published online: December 02, 2008
Number of Print Pages : 10

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