Disturbances of Trace Element Concentrations in Plasma of Patients with Chronic Renal Failure

Vol. 26, No. 4, 1980

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Original Paper

Disturbances of Trace Element Concentrations in Plasma of Patients with Chronic Renal Failure
Yusuke Tsukamoto, Shigeru Iwanami, Fumiaki Marumo

Departments of Medicine and Radiology, Kitasato University School of Medicine, Kitasato

Address of Corresponding Author

Nephron 1980;26:174-179 (DOI: 10.1159/000181976)

Key Words

Trace elements
Aluminium
Zinc
Uremia
Hemodialysis

Abstract

Plasma concentrations of 6 essential trace elements were measured in undialyzed and hemodialyzed patients with chronic renal failure (CRF) and in healthy volunteers by tube-excited X-ray fluorescence analysis and atomic absorption analysis. The influences of hemodialysis on plasma concentrations of Al, Zn, Cu and Br were also studied. High plasma concentrations of Al and Cu and low concentrations of plasma Zn were found in nondialyzed patients with CRF. Plasma concentrations of Al and Cu increased and Zn and Br decreased in the hemodialyzed patients with CRF. An elevated concentration of plasma Al may be primarily caused by permeation from dialysate across the dialyzer membrane. The use of water produced by reverse osmosis will prevent the elevation of plasma Al concentration in patients with CRF.

Author Contacts

Dr. Y. Tsukamoto, Department of Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa 228 (Japan)

Article Information

Accepted: March 10, 1980
Published online: December 02, 2008
Number of Print Pages : 6

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