Original Paper

Gouty Kidney Associated with Membranous Nephropathy: Participation of Renal Tubular Epithelial Antigen
Hitoshi Yokoyama, Hiroshi Kida, Teruo Asamato, Toshio Abe, Yoshitaka Koshino, Nobu Hattori

First Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan

Address of Corresponding Author

Nephron 1986;44:361-364 (DOI: 10.1159/000184021)

  Key Words

• Gouty kidney
• Membranous nephropathy
• Renal tubular antigen

  Abstract

Histological studies were performed on 3 patients with gout and proteinuria measured at 1.0 g a day or more. Light microscopy revealed diffuse thickening of the glomerular capillary walls accompanied by spike formation and bubble-like appearance as well as tophaceous granuloma in the interstitium, tubular atrophy and benign nephrosclerosis. Immunofluorescence technique showed fine granular deposits of IgG and C3 along the glomerular capillary walls together with the renal tubular epithelial antigen (RTE) in 1 patient. Subepithelial dense deposits were also observed by electron microscopy. These findings suggest that the association of membranous nephropathy should be considered in patients with gout having moderate to severe proteinuria and that RTE may be involved in the pathogenesis of subepithelial deposits in gouty membranous nephropathy.

Copyright © 1986 S. Karger AG, Basel

  Author Contacts

Hitoshi Yokoyama MD, First Department of Internal Medicine, School of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa 920 (Japan)

  Article Information

Accepted: April 8, 1986
Published online: December 05, 2008
Number of Print Pages : 4