Influence of Proteinuria on Long-Term Transplant Survival in Kidney Transplant Recipients

Vol. 75, No. 2, 1997

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Original Paper

Influence of Proteinuria on Long-Term Transplant Survival in Kidney Transplant Recipients
H. Hohage^a, U. Kleyer^a, D. Bruckner^a, C. August^b, W. Zidek^a, C. Spieker^a

^aMedical Department D and
^bInstitute of Pathology, University of Münster, Germany

Address of Corresponding Author

Nephron 1997;75:160-165 (DOI: 10.1159/000189525)

Key Words

Proteinuria
Kidney transplantation
Transplant survival

Abstract

Long-term prognosis in kidney transplant recipients depends on multiple factors. To investigate whether mild proteinuria within the first 6 months following transplantation is a determinant of the long-term function and survival of kidney transplants, 357 patients transplanted between 1980 and 1990 were retrospectively examined over a period of 5 years. 25.5% of the patients developed an early proteinuria between 0.25 and 1.0 g/day over 6 or more months. This group was well matched concerning gender, age of recipient, underlying disease, time on hemodialysis, donor age, cold ischemia time and HLA mismatches with the group without proteinuria (n = 266). Five-year transplant survival in the group with proteinuria was 58.9% in contrast to 85.6% in recipients without proteinuria. Intermittent proteinuria did not worsen long-term prognosis. Proteinuria of 12 months or longer further reduced 5-year transplant survival to 42.6%. Over the whole observation period, serum creatinine in recipients with proteinuria was about 0.5 mg/dl higher as compared with patients without proteinuria. No correlation between proteinuria and gender, age of recipient, duration of hemodialysis, age of donor, cold ischemia time and mismatches could be detected. In conclusion, early proteinuria apparently is not due to established donor or recipient factors. However, there is a strong correlation of proteinuria with worse transplant function and survival.

Author Contacts

Dr. Helge Hohage, Medical Department D, University of Münster, Albert Schweitzer Strasse 33, D-48129 Münster (Germany)

Article Information

Accepted: April 11, 1996
Published online: December 19, 2008
Number of Print Pages : 6

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