Randomized Trial of a Low-Molecular-Weight Heparin (Kabi 2165) versus Adjusted-Dose Subcutaneous Standard Heparin in the Prophylaxis of Deep-Vein Thrombosis after Elective Hip Surgery

Vol. 19, No. 1, 1989

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Original Paper

Randomized Trial of a Low-Molecular-Weight Heparin (Kabi 2165) versus Adjusted-Dose Subcutaneous Standard Heparin in the Prophylaxis of Deep-Vein Thrombosis after Elective Hip Surgery
M. Dechavanne^a, D. Ville^a, M. Berruyer^a, F. Trepo^b, F. Dalery^b, N. Clermont^c, J.L. Lerat^b, B. Moyen^b, L.P. Fischer^c, A. Kher^d, P. Barbier^d

^aLaboratoires d'Hémostase et de Médecine nucléaire,
^bService de Chirurgie orthopédique et de Médecine du Sport,
^cClinique de Chirurgie orthopédique, Hôpital E. Herriot, Lyon, et
^dLaboratoire KabiVitrum, Noisy-le-Grand, France

Address of Corresponding Author

Haemostasis 1989;19:5-12 (DOI: 10.1159/000215882)

Key Words

Deep-vein thrombosis
Heparin, low-molecular-weight
Hip surgery

Abstract

124 patients undergoing total hip replacement were randomly allocated to receive Kabi 2165, 2,500 anti-Xa units twice a day (group A); Kabi 2165, 2,500 anti-Xa units twice a day during the first 48 h postoperatively and then 5,000 anti-Xa units once a day (group B), or adjusted-dose standard heparin, monitored by activated partial thromboplastin time (group C). The first dose was given 2 h before surgery in the three groups. Deep-vein thrombosis (DVT) was detected by radiolabelled fibrinogen uptake and bilateral venography was performed in patients who had a positive scan. In patients who had a negative scan, bilateral venography was performed routinely the day before discharge from hospital. The frequency of DVT demonstrated by venography was 4.9% in group A, 7.3% in group B and 10% in group C. The difference between the three groups was not statistically significant. The incidence of proximal DVT was 2.4, 2.4 and 7.5%, respectively, for the three groups. There was no significant difference between the three groups with respect to mean estimated blood loss, the number of blood units transfused, wound hematoma formation, or hemoglobin and hematocrit levels.

Author Contacts

M. Dechavanne, MD, Laboratoires d'Hémostase et de, Médecine nucléaire, Hôpital E. Herriot, F-69374 Lyon (France)

Article Information

Received: December 11, 1987
Accepted: March 25, 1988
Published online: April 24, 2009
Number of Print Pages : 8

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