Fosfomycin.
Editor(s): Rubio J.M. (Madrid), Gallego A. (Madrid)

Different Infections

Surgical Suppurating Infections and Surgical Abdominal Infections Treated with Fosfomycin
A. Gallardo, J.M. Sáez, G. Enriquez, A.R. Cobacho, R. Torronteras, C. Recordan, Del Moral, A. Arroyo, A.G. Curiel

Departamento de Cirugía (Dr. T. Charlo Dupont), Departamento de Cirugía de Urgencia (Dr. A. Gallardo), y Departamento de Bacteriología (Dr. A. R. Cobacho), Ciudad Sanitaria 'Vírgen del Rocío' de la Seguridad Social, Sevilla

Address of Corresponding Author

Chemotherapy 1977;23 (Suppl. 1):392-398 (DOI: 10.1159/000222080)

  Key Words

• Fosfomycin
• Suppurating surgical infections
• Abdomen surgical infections

  Abstract

Two groups of patients suffering surgical infections were treated with fosfomycin. The first includes 21 suppurating dermic or soft underlying tissue lesions. The second group includes 29 surgical abdominal infections. The bacteriology of the first group was made up of gram-positive and gram-negative germs predominantly S. aureus and E. coli, all the isolated species appeared to be sensitive to fosfomycin. In the second group a gram-negative bacterial flora predominantly E. coli was obtained; with a sensitivity to this antibiotic of 90.5%. Surgical treatment accompanied the treatment with fosfomycin. In the first group, all the patients were cured with the oral administration of 2-6 g/day and in an average time less than that of the similar control group which did not receive the antibiotic. In the second group surgical treatment was necessary in 25 of the 29 patients and in all of them parenteral treatment was done with fosfomycin, preferably intramuscularly and in general the dosage was 4 g daily. All patients were cured except for one who was not operated on and who suffered from a fever of undetermined origin.

Copyright © 1977 S. Karger AG, Basel

  Author Contacts

Dr. A. Gallardo, Calle Eduardo Dato, 26, Sevilla (Spain)

  Article Information

Number of Print Pages : 7