Original Paper

Immunohistochemical Evaluation of Estrogen Receptor Status in Benign Prostatic Hypertrophy and in Prostate Carcinoma and the Relationship to Efficacy of Endocrine Therapy
Noboru Konishi^a, Shingo Nakaoka^a, Yoshio Hiasa^a, Yoshiteru Kitahori^a, Masato Ohshima^a, Shoji Samma^b, Eigoro Okajima<sup>b

a</sup>Second Department of Pathology and
^bDepartment of Urology, Nara Medical University, Kashihara, Nara, Japan

Address of Corresponding Author

Oncology 1993;50:259-263 (DOI: 10.1159/000227191)

  Key Words

• Prostate carcinoma
• Estrogen receptor
• Hormone therapy

  Abstract

The levels of estrogen receptors in human benign prostatic hypertrophy and in various pathological classifications of prostate carcinoma were assessed using immunohistochemical methods. All cases of benign hypertrophy showed elevated levels of estrogen receptor, while receptor-positive cells were detected in only 48% of carcinomas, indicating a negative correlation between receptor status and malignancy. Furthermore, the prognosis for effective endocrine therapy was poor in cases where tissues demonstrated low or negative receptor levels. In addition, the estrogen receptor status was compared to cell kinetic index such as proliferating cell nuclear antigen and argyrophilic staining of the nuclear organizer region.

Copyright © 1993 S. Karger AG, Basel

  Author Contacts

Dr. Noboru Konishi, Second Department of Pathology, Nara Medical University, Kashihara, Nara 634 (Japan)

  Article Information

Published online: June 26, 2009
Number of Print Pages : 5