Penetration of Minocycline Hydrochloride into Lung Tissue and Sputum

Vol. 47, No. 1, 2001

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Pharmacology

Penetration of Minocycline Hydrochloride into Lung Tissue and Sputum
Akira Watanabe^a, Yoshiyuki Anzai^b, Katsunao Niitsuma^c, Miwako Saito^c, Kenji Yanase^d, Mikae Nakamura^d

^aDepartment of Respiratory Oncology and Molecular Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai,
^bDepartment of Respiratory Medicine, Takeda General Hospital, Aizu-Wakamatsu,
^cDepartment of Internal Medicine, Aizu General Hospital, Aizu-Wakamatsu,
^dDepartment of Respiratory Medicine, Seirei Mikatahara General Hospital, Hamamatsu, Japan

Address of Corresponding Author

Chemotherapy 2001;47:1-9 (DOI: 10.1159/000048494)

Key Words

Minocycline hydrochloride
Pharmacokinetics
Lung tissue
Sputum
Drip infusion

Abstract

Penetration of minocycline hydrochloride (MINO) into lung tissue and sputum was investigated. MINO (100 mg) was intravenously infused over 30 min to 14 patients before lung surgery: the concentration of MINO was determined in 16 lung tissue samples which were collected between 0.25 and 5.0 h after infusion. The mean concentration of MINO in lung tissue sample was 2.92 ± 1.43 µg/g, and the mean lung tissue/plasma ratio of MINO concentration was 3.71 ± 2.36. MINO was infused intravenously over 60 min twice daily to 5 patients with a chronic respiratory disease for 3-7 days. The concentration of MINO in sputum and in serum was determined on day 3. The mean maximum concentration of MINO in sputum sample was 2.12 ± 2.20 µg/g, and the mean sputum/serum ratio of MINO concentration was 0.56 ± 0.47. The concentration of MINO in sputum showed little time-related variation and remained as high as 0.74 µg/g until 10 h after infusion. The concentration of MINO in sputum and in serum after intravenous drip infusion was about twice as high as that after oral administration at the same dose. The breakpoint was 1.88 for MINO, as calculated by the formula established by the Japan Society of Chemotherapy.

Author Contacts

Akira Watanabe, MD
Department of Respiratory Oncology and Molecular Medicine
Institute of Development, Aging and Cancer, Tohoku University
4-1, Seiryo-cho, Aoba-ku, Sendai 980-8575 (Japan)
Tel./Fax +81 22 717 8540

Article Information

Number of Print Pages : 9
Number of Figures : 2, Number of Tables : 3, Number of References : 17

Medline Abstract (ID 11125226)

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