Original Paper · Travail original · Originalarbeit

Topical 0.1% Indomethacin Solution versus Topical 0.1% Dexamethasone Solution in the Prevention of Inflammation after Cataract Surgery
Luc Missotten^a, Christine Richard^b, Claude Trinquand^b, and the Study Group<sup>1

a</sup>Universitair Ziekenhuis, Leuven, Belgium;
^bLaboratoire Chauvin, Montpellier, France

Address of Corresponding Author

Ophthalmologica 2001;215:43-50 (DOI: 10.1159/000050825)

  Key Words

• Cataract surgery
• Inflammation, post-operative
• Indomethacin
• Dexamethasone

  Abstract

Purpose: To compare the efficacy and safety of topical 0.1% indomethacin with 0.1% dexamethasone after cataract surgery. Methods: 145 patients (indo = 71, dexa = 74) were enrolled in a randomised, double-masked study and received one drop 4 times a day of indomethacin or dexamethasone for 1 month. Results: Proteinic flare and cellular Tyndall decreased with time in both groups, with a difference in favour of indomethacin for cellular Tyndall on day 30 (p = 0.046). Conjunctival hyperaemia was less pronounced in the dexamethasone group on day 30 (p = 0.03). Tolerance of both drugs was good. Conclusion: 0.1% Indomethacin solution appears to be as safe and efficient as 0.1% dexamethasone eyedrops in the management of post-operative inflammation and could be a good alternative to the use of steroids.

Copyright © 2001 S. Karger AG, Basel

  Author Contacts

Christine Richard, MD
Laboratoire Chauvin, 416 rue Samuel Morse, BP 1174
F-34009 Montpellier Cedex 1 (France)
Tel. +33 4 67 12 30 46, Fax +33 4 67 12 30 36
E-Mail crichard@chauvingroup.com

  Article Information

Received: Received: February 24, 2000
Accepted: March 8, 2000
Number of Print Pages : 8
Number of Figures : 4, Number of Tables : 3, Number of References : 13