Address of Corresponding Author

Dermatology 2004;209:202-207 (DOI: 10.1159/000079890)

  Key Words

• Finasteride
• Female pattern hair loss
• Postmenopausal women
• Normoandrogenic alopecia

  Abstract

Background: Finasteride, an inhibitor of type 2 5-reductase, inhibits conversion of testosterone to dihydrotestosterone, resulting in a decrease in serum and scalp dihydrotestosterone levels believed to be pathogenic in androgenetic alopecia. Oral finasteride has been shown to be effective in the treatment of hair loss in men, while its efficacy in women has remained controversial. Methods: 5 postmenopausal women without clinical or laboratory signs of hyperandrogenism were given 2.5 or 5 mg/day oral finasteride for the treatment of pattern hair loss. Efficacy was evaluated by patient and investigator assessments, and review of photographs taken at baseline and at months 6, 12 and 18 by an expert panel. Results: Finasteride treatment improved scalp hair by all evaluation techniques. The patients' self-assessment demonstrated that finasteride treatment decreased hair loss, increased hair growth and improved appearance of hair. These improvements were confirmed by investigator assessment and assessments of photographs. No adverse effects were noted. Conclusions: Oral finasteride in a dosage of 2.5 mg/day or more may be effective for the treatment of pattern hair loss in postmenopausal women in the absence of clinical or laboratory signs of hyperandrogenism.

Copyright © 2004 S. Karger AG, Basel

  Author Contacts

Ralph M. Trüeb, MD
Department of Dermatology
University Hospital of Zurich, Gloriastrasse 31
CH-8091 Zurich (Switzerland)
Tel. +41 44 255 2593, Fax +41 44 255 4403, E-Mail Ralph.Trueeb@usz.ch

  Article Information

Received: February 13, 2004
Accepted: May 14, 2004
Number of Print Pages : 6
Number of Figures : 3, Number of Tables : 2, Number of References : 25