Effect of Hemodiafiltration against Radical Stress in the Course of Blood Purification

Vol. 22, Suppl. 2, 2004

Free Abstract Article (References) Article (PDF 136 KB)

9th Annual Conference of the Japanese Society for Hemodiafiltration in Conjunction with the International Symposium on Hemodiafiltration Therapy
August 30-31, 2003, Kanagawa, Japan
Selected Papers
Editor: Akihiro C. Yamashita, Kanagawa

Luncheon Seminar

Effect of Hemodiafiltration against Radical Stress in the Course of Blood Purification
Tadashi Tomo, Kazuhiro Matsuyama, Masaru Nasu

Second Department of Internal Medicine, Oita University, Faculty of Medicine, Hazama, Japan

Address of Corresponding Author

Blood Purif 2004;22 (Suppl. 2):72-77 (DOI: 10.1159/000081879)

Key Words

Hemodiafiltration
Hydroperoxide radical
Hydroxy radical
Advanced glycation end products

Abstract

The involvement of radical stress has been suggested as a cause for complications in patients on dialysis, such as arteriosclerosis, dialysis-related amyloidosis, etc. It has been reported that the increase in radical stress is not only seen in renal failure, but that its amplified effect is also seen in the process of blood purification. Our group has reported on the radical stress-reducing effect of HDF. We performed four types of blood purification (HD; on-line HDF; pre, on-line HDF; post, P/P HDF) in patients on maintenance dialysis using the polysulfone (APS) dialyzer. The change in radical related markers such as pentosidine (total, free) and CML (total, free), and the CTL/Cr ratio, and the hydroperoxide radicals were studied. In HDF (post, pre), the amplification rate of hydroperoxide radicals was significantly low, whereas the reduction rate of CTL/Cr ratio as index for hydroxy radicals was significantly higher in on-line HDF than in HD. Both the total CML and T-pentosidine increased in HD but showed a decrease in HDF. As HDF uses large amounts of replacement solution, the following effects can be expected: (a) suppression of the amplification of hydroperoxide radicals and suppression of the amplification of hydroxy radicals, and (b) suppression of fat oxidation by AGEs themselves. These antiradical stress effects are presumed to be exerted by effective removal of radical carrier protein, denatured protein, and complement protein in HDF, by dilution of radicals by massive use of replacement solution, and by the sequential reduction of the excitation and amplification effects.

Author Contacts

Tadashi Tomo
Second Department of Internal Medicine, Faculty of Medicine, Oita University
Idaigaoka 1-1, Hazama-machi
Oita 879-5593 (Japan)
Tel. +81 97 586 5804, Fax +81 97 549 4245, E-Mail tomo@med.oita-u.ac.jp

Article Information

Number of Print Pages : 6
Number of Figures : 8, Number of Tables : 0, Number of References : 13

Medline Abstract (ID 15655328)

Download Citation

Cited In

This journal is part of the third subject package of the Karger

Journal Archive Collection

Information on packages (PDF)
Free sample issues

For non-native English speakers and international authors who would like assistance with their writing before submission, we suggest American Journal Experts for their scientific editing service.