Address of Corresponding Author

Chemotherapy 2006;52:9-11 (DOI: 10.1159/000090234)

  Key Words

• Prostatitis syndrome
• Ureaplasma urealyticum
• Azithromycin
• Doxycycline

  Abstract

A total of 1,442 patients with symptoms of chronic prostatitis were examined over a 4-year period at the Outpatient Department for Urogenital Infections, University Hospital for Infectious Diseases Dr. Fran Mihaljevi, Zagreb, Croatia. The inclusion criteria for chronic prostatitis caused by Ureaplasma urealyticum were the presence of clinical symptoms, presence of U. urealyticum in expressed prostatic secretion (EPS) or voided urine collected immediately after prostatic massage (VB₃), absence of U. urealyticum in urethral swabs and absence of other possible pathogens of chronic prostatitis in EPS or VB₃. A total of 63 patients with prostate infection caused by U. urealyticum were available for this pilot study. The patients were randomized according to a computer randomization list to receive a total dose of 4.5 g of azithromycin given as a 3-day therapy of 1 × 500 mg weekly for 3 weeks or doxycyline 100 mg b.i.d. for 21 days. Patients' sexual partners were treated at the same time. Clinical efficacy and tolerability of the administered drug as well as possible adverse events were evaluated during, at the end and 4-6 weeks after completion of therapy. Bacteriological efficacy was evaluated 4-6 weeks after completion of therapy. Treatment groups did not differ regarding age, distribution of urethral, prostatic, sexual and other symptoms, or digitorectal prostatic examination. Five patients treated with doxycycline had nausea. In the group of patients with prostate infection caused by U. urealyticum, the eradication rate was not significantly different with regard to the administered azithromycin (25/32) or doxycycline (23/31). Clinical cure did not significantly differ with regard to the administered azithromycin (22/32) or doxycycline (21/31).

Copyright © 2006 S. Karger AG, Basel

  Author Contacts

Prof. Višnja kerk, MD, PhD
University Hospital for Infectious Diseases Dr. Fran Mihaljevi
Mirogojska 8
10 000 Zagreb (Croatia)
Tel. +385 1 46 03 222, Fax +385 1 46 03 295, E-Mail bfm@bfm.hr

  Article Information

Presented at the 1st World Conference on Magic Bullets - EHRLICH 2004, Nürnberg, Germany, September 9-11, 2004.

Received: August 13, 2004
Accepted after revision: June 20, 2005
Published online: December 9, 2005
Number of Print Pages : 3
Number of Figures : 0, Number of Tables : 0, Number of References : 12