Ramosetron versus Ondansetron in the Prevention of Chemotherapy-Induced Gastrointestinal Side Effects: A Prospective Randomized Controlled Study

Vol. 53, No. 1, 2007

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Clinical Study

Ramosetron versus Ondansetron in the Prevention of Chemotherapy-Induced Gastrointestinal Side Effects: A Prospective Randomized Controlled Study
Yuankai Shi, Xiaohui He, Sheng Yang, Bin Ai, Changgong Zhang, Dingzhi Huang, Mei Dong, Peng Liu, Shengyu Zhou, Xiaohong Han

Department of Medical Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Address of Corresponding Author

Chemotherapy 2007;53:44-50 (DOI: 10.1159/000098418)

Key Words

Ramosetron
Ondansetron
5-Hydroxytryptamine receptor 3 antagonist
Emesis

Abstract

Background: This study observed and compared the preventive effects of ramosetron and ondansetron on gastrointestinal side effects caused by cisplatin-containing chemotherapy. Methods: Fifty patients with malignant tumors undergoing their first chemotherapy were randomly divided into two groups, and each group received 0.3 mg of ramosetron and 16 mg of ondansetron in a prospective crossover comparison study. Results: Data were collected for analysis of the therapeutic effect in 47 cases and for adverse events in 50 cases. Both drugs showed similar results in regard to chemotherapy-induced gastrointestinal side effects, emesis and appetite loss on day 1, but by day 5, ramosetron was significantly better than ondansetron in terms of controlling appetite loss. From days 3-5, ramosetron tended to be more effective than ondansetron in its antiemetic action. The incidence of headache, fatigue and constipation was the same for both drugs. Conclusions: Ramosetron is a long-lasting and safe antiemetic agent.

Author Contacts

Dr. Yuankai Shi
Department of Medical Oncology, Cancer Institute and Hospital
Chinese Academy of Medical Sciences and Peking Union Medical College
100021 Beijing (China)
Tel. +86 10 8777 88269, Fax +86 10 6770 5068, E-Mail syk@pubem.cicams.ac.cn

Article Information

Received: June 27, 2005
Accepted after revision: January 17, 2006
Published online: January 3, 2007
Number of Print Pages : 7
Number of Figures : 0, Number of Tables : 5, Number of References : 18

Medline Abstract (ID 17202811)

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