A new contribution to the integration of human and porcine genome maps: 623 new points of homology

Vol. 102, No. 1-4, 2003

Free Abstract Article (Fulltext) Article (PDF 460 KB)

Animal Genomics
Editor: Bhanu Chowdhary, College Station, Tex.

Paper

A new contribution to the integration of human and porcine genome maps: 623 new points of homology
A. Robic^a, T. Faraut^a, N. Iannuccelli^a, Y. Lahbib-Mansais^a, V. Cantegrel^a, L. Alexander^b, D. Milan^a

^aInstitut National de la Recherche Agronomique (INRA), Laboratoire de Génétique Cellulaire, BP27, Castanet Tolosan (France);
^bDepartment of Veterinary PathoBiology, College of Veterinary Medicine, University of Minnesota, St Paul MN (USA)

Address of Corresponding Author

Cytogenet Genome Res 2003;102:100-108 (DOI: 10.1159/000075733)

Abstract.

In this study we examined homologies between 1,735 porcine microsatellites and human sequence. For 1,710 microsatellites we directly used the sequence flanking the repeat available in GenBank. For a set of 305 microsatellites, a BAC library was screened and end-sequencing provided 461 additional sequences. Altogether 2,171 porcine sequences were tentatively aligned with the sequence of the human genome using the fasta program. Human homologies were observed for 652 microsatellite loci and porcine chromosome assignments available for 623 microsatellites provide useful links in the human and pig comparative map. Moreover for 92 STS, a significant sequence similarity was detected using at least two sequences and in all cases corresponding human locations were consistent. The present study allowed the integration of anonymous markers and the porcine linkage map into the framework of the comparative data between human and porcine genomes (http://w3.toulouse.inra.fr/lgc/pig/msat/). Moreover all conserved syntenic segments were defined on human chromosomes.

Author Contacts

Request reprints from Annie Robic, INRA
Laboratoire de Génétique Cellulaire, BP27
31326 Castanet Tolosan Cedex (France)
telephone: (33) 05 61 28 51 15; fax: (33) 05 61 28 53 08
e-mail: arobic@toulouse.inra.fr

Article Information

Supported by grants from the French program “AGENAE''.

Received 6 May 2003;
manuscript accepted 28 July 2003.
Number of Print Pages : 9
Number of Figures : 2, Number of Tables : 3, Number of References : 22

Medline Abstract (ID 14970687)

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