Impact of Meal Timing and Frequency on the Twenty-Four-Hour Leptin Rhythm

Vol. 62, No. 2, 2004

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Original Paper

Impact of Meal Timing and Frequency on the Twenty-Four-Hour Leptin Rhythm
A.J. Fogteloo^a, H. Pijl^a, F. Roelfsema^a, M. Frölich^b, A.E. Meinders^a

Departments of
^aGeneral Internal Medicine and
^bClinical Chemistry, Leiden University Medical Center, Leiden, TheNetherlands

Address of Corresponding Author

Horm Res 2004;62:71-78 (DOI: 10.1159/000079326)

Key Words

Diurnal leptin rhythm
Tenty-four-hour leptin rhythm

Abstract

Objective: To study the influence of changes in meal timing and frequency on the diurnal rhythm of leptin and on the 24-hour profile of insulin and glucose. Patients and Methods: Five obese women were studied twice during a weight-maintaining diet in either 3 daily or 8 day and night equal portions. Blood was sampled for 24-hour profiles of leptin and insulin. Results: During the 8-meal intervention, the 24-hour rhythm of leptin changed significantly: the amplitude decreased (p = 0.0089) and the acrophase was delayed by 168 min (p = 0.021). Also, 8 small insulin secretion peaks occurred instead of the 3 postprandial high insulin peaks. Conclusion: The dispersion of food intake over 24 h affects the diurnal leptin rhythm. These changes could not be attributed to changes in circadian timing or energy balance. Instead, changes in daily insulin secretion profiles might play a role.

Author Contacts

A.J. Fogteloo
Department of General Internal Medicine
Leiden University Medical Center, C1-R51, PO Box 9600
NL-2300 RC Leiden (The Netherlands)
Tel. +31 71 526 3504, Fax +31 71 524 8140, E-Mail a.j.fogteloo@lumc.nl

Article Information

Received: November 28, 2003
Accepted: April 20, 2004
Published online: June 21, 2004
Number of Print Pages : 8
Number of Figures : 3, Number of Tables : 4, Number of References : 26

Medline Abstract (ID 15218336)

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