Efficacy and Safety of 0.1% Retinaldehyde/ 6% Glycolic Acid (Diacnéal<sup>®</sup>) for Mild to Moderate Acne vulgaris

Vol. 210, Suppl. 1, 2005

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RALGA The First Association of Retinaldehyde and Glycolic Acid. A New Compound for the Acne Patient with Depigmenting Properties. Based on a Satellite Symposium Held at the 12th Congress of the EADV, Barcelona, October 2003. Chaired by: W.J. Cunliffe, B. Dréno, A. Katsambas, H. Gollnick and J.-H. Saurat

Biochemistry

Efficacy and Safety of 0.1% Retinaldehyde/ 6% Glycolic Acid (Diacnéal^®) for Mild to Moderate Acne vulgaris
A Multicentre, Double-Blind, Randomized, Vehicle-Controlled Trial
F. Poli^a, V. Ribet^b, C. Lauze^b, H. Adhoute^a, P. Morinet^b

^aParis and
^bPierre Fabre Research Institute, Vigoulet-Auzil, France

Address of Corresponding Author

Dermatology 2005;210 (Suppl. 1):14-21 (DOI: 10.1159/000081498)

Key Words

Acne vulgaris
Retinaldehyde
Glycolic acid

Abstract

Background: Retinaldehyde and glycolic acid are both efficient in acne. Objective: To evaluate the efficacy and tolerability of a 0.1% retinaldehyde/6% glycolic acid combination (Diacnéal^®) for mild to moderate acne vulgaris. Methods: Overall physician and patient ratings of acne symptom severity and tolerance were performed at baseline, months 1, 2 and 3. Results: Mean numbers of papules, pustules and comedones were significantly reduced from month 1 onwards. A significant advantage of Diacnéal over vehicle was demonstrated on the percentages of patients with ongoing healing lesions at month 2, healing ancient lesions from month 1 and patients with 'important/very important' global improvement from month 2 (50.0 vs. 26.3%) confirmed by patients at month 3 (86.1 vs. 58.8%). Products were well tolerated; only 1 patient had to stop the treatment. Conclusions: Diacnéal, a combination of 0.1% retinaldehyde/6% glycolic acid, is effective and well tolerated in mild to moderate acne vulgaris.

Author Contacts

F. Poli
2, rue du Cherche Midi
FR-75006 Paris (France)
Tel. +33 145 490 248, Fax +33 145 491 718
E-Mail florence.poli@hmn.ap-hop-paris.fr

Article Information

Number of Print Pages : 8
Number of Figures : 3, Number of Tables : 2, Number of References : 10

Medline Abstract (ID 15724103)

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