RALGA (Diacnéal<sup>®</sup>), a Retinaldehyde and Glycolic Acid Association and Postinflammatory Hyperpigmentation in Acne – A Review

Vol. 210, Suppl. 1, 2005

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RALGA The First Association of Retinaldehyde and Glycolic Acid. A New Compound for the Acne Patient with Depigmenting Properties. Based on a Satellite Symposium Held at the 12th Congress of the EADV, Barcelona, October 2003. Chaired by: W.J. Cunliffe, B. Dréno, A. Katsambas, H. Gollnick and J.-H. Saurat

Biochemistry

RALGA (Diacnéal^®), a Retinaldehyde and Glycolic Acid Association and Postinflammatory Hyperpigmentation in Acne - A Review
A.D. Katsambas

'A. Sygros' Hospital, University of Athens, Athens, Greece

Address of Corresponding Author

Dermatology 2005;210 (Suppl. 1):39-45 (DOI: 10.1159/000081501)

Key Words

Retinaldehyde
Glycolic acid
Acne
Hyperpigmentation

Abstract

Acne vulgaris affects 3 out of 4 adolescents and usually vanishes at the end of puberty with either no sequelae or mild to moderate sequelae, such as postinflammatory hyperpigmenation (PIH), which may result in psychological and emotional damages. The poor tolerability of the actual treatments (secondary inflammation) is a hindrance to therapy. Retinaldehyde (RAL), a precursor of retinoic acid, has shown depigmenting activity. Glycolic acid (GA) decreases the excess of pigment by a wounding and re-epithelization process. Thus, a synergistic effect was expected from the combination of RAL 0.1% and GA 6% RALGA (Diacnéal^®) in the treatment of acne vulgaris and PIH. Efficacy results of preclinical and clinical trials tend to confirm the expectations for both acne and PIH treatment. A good tolerability was observed. In conclusion, the cosmetic cream Diacnéal is a well-tolerated treatment for the prevention and healing of PIH in acne patients.

Author Contacts

Prof. Andreas Katsambas
35 Skoufa Street
GR-106 73 Athens (Greece)
Tel. +30 210 36 17 778, Fax +30 210 36 00 196
E-Mail katsabas@internet.gr

Article Information

Number of Print Pages : 7
Number of Figures : 4, Number of Tables : 0, Number of References : 51

Medline Abstract (ID 15724107)

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