DNA Microarray Analysis of Pancreatic Malignancies

Vol. 4, No. 6, 2004

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Review

DNA Microarray Analysis of Pancreatic Malignancies
Regine Brandt^a, Robert Grützmann^b, Andrea Bauer^c, Ralf Jesnowski^a,d, Jörg Ringel^a, Matthias Löhr^a,d, Christian Pilarsky^b, Jörg D. Hoheisel^c

^aDepartment of Medicine II, Mannheim Medical Faculty, University of Heidelberg, Mannheim;
^bDepartment of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University of Dresden;
^cDivision of Functional Genome Analysis, and
^dMolecular Gastroenterology Unit, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany

Address of Corresponding Author

Pancreatology 2004;4:587-597 (DOI: 10.1159/000082241)

Key Words

Pancreatic ductal carcinoma
Microarray
Gene expression profiling
Cancer, pancreas

Abstract

Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis. To improve the prognosis, novel molecular markers and targets for earlier diagnosis and adjuvant and/or neoadjuvant treatment are needed. Recent advances in human genome research and high-throughput molecular technologies make it possible to cope with the molecular complexity of malignant tumors. With DNA array technology, mRNA expression levels of thousand of genes can be measured simultaneously in a single assay. As several studies using microarrays in PDAC have already been published, this review attempts to compare the published data and therefore to validate the results. In addition, the applied techniques are discussed in the context of pancreatic malignancies.

Author Contacts

Jörg D. Hoheisel, PhD
Division of Functional Genome Analysis, Deutsches Krebsforschungszentrum
Im Neuenheimer Feld 580
DE-69120 Heidelberg (Germany)
Tel. +49 6221 424680, Fax +49 6221 424682, E-Mail j.hoheisel@dkfz.de

Article Information

Regine Brandt and Robert Grützmann contributed equally to this study.

Published online: November 19, 2004
Number of Print Pages : 11
Number of Figures : 0, Number of Tables : 3, Number of References : 75

Medline Abstract (ID 15557762)

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