Ethnic Differences in Cerebral Venous Thrombosis

Vol. 19, No. 3, 2005

Free Abstract Article (Fulltext) Article (PDF 99 KB)

Original Paper

Ethnic Differences in Cerebral Venous Thrombosis
Érica Cristina Sá de Camargo^a, Ayrton Roberto Massaro^a, Luiz Alberto Bacheschi^{a, b}, Élbio Antônio D'Amico^c, Paula Ribeiro Villaça^c, Rogério Pastore Bassitt^c, Sandra Fátima Gualandro^c, Israel Bendit^c, Milberto Scaff^a

Departments of
^aNeurology,
^bRadiology,and
^cHematology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

Address of Corresponding Author

Cerebrovasc Dis 2005;19:147-151 (DOI: 10.1159/000083247)

Key Words

Venous thrombosis
Cerebral veins
Ethnic groups
Thrombophilia
Prognosis

Abstract

Background: Cerebral venous thromboses (CVT) with distinct clinical presentations have been shown worldwide. However, there is little information regarding race-ethnic differences in this disease. Methods: We prospectively studied 50 CVT patients from Brazil, comparing clinical and laboratory data among white (W) and African-Brazilian (AB) patients. Results: Seventy percent of the patients were female, 26 W and 23 AB, mean age 34.7 years. Multiple sinus CVT, deep CVT and worse outcome were significantly more frequent in AB than in W patients. There was a trend towards a higher frequency of factor V Leiden and prothrombin mutation in W than in AB, and of protein C deficiency in AB. Conclusions: CVT was more severe in AB patients than in W patients. Race-ethnic differences may account for the heterogeneous distribution of inherited thrombophilia in this series.

Author Contacts

Érica Cristina Sá de Camargo, MD
MGH-Stroke Service, VBK-802
55 Fruit St., Boston, MA 02114 (USA)
Tel. +1 617 726 0559, Fax +1 617 726 5043
E-Mail ecamargo@partners.org

Article Information

Received: January 14, 2004
Accepted: August 31, 2004
Published online: January 11, 2005
Number of Print Pages : 5
Number of Figures : 0, Number of Tables : 1, Number of References : 19

Medline Abstract (ID 15644626)

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