Optimization of Prostatic Biopsy: A Prospective Randomized Trial Comparing the Sextant Biopsy with a 10-Core Biopsy

Vol. 74, No. 3, 2005

Free Abstract Article (References) Article (PDF 183 KB)

Original Paper

Optimization of Prostatic Biopsy: A Prospective Randomized Trial Comparing the Sextant Biopsy with a 10-Core Biopsy
Roger Paul^a, Stefan Schöler^a, Heiner van Randenborgh^a, Hubert Kübler^a, Michael Alschibaja^a, Raymonde Busch^b, Rudolf Hartung^a

^aDepartment of Urology and
^bInstitute of Medical Statistics and Epidemiology, Technische Universität Munich, Klinikum rechts der Isar, Munich, Germany

Address of Corresponding Author

Urol Int 2005;74:203-208 (DOI: 10.1159/000083549)

Key Words

Prostatic biopsy
Prostate cancer detection rate
Prostate cancer, morbidity

Abstract

Objective: New prostatic biopsy protocols suggest to increase the core numbers to enhance detection. Additional cores are usually sampled from the lateral part of the p-zone. We direct the sextant biopsy to the most lateral part of the p-zone, therefore we investigated if there is a gain by adding 4 median biopsy cores. Material and Methods: The prospective randomized trial (n = 200) compared our modified sextant biopsy to a 10-core strategy with 2 additional median cores on both sides. Directed biopsies to suspicious areas were allowed in both groups. Morbidity was assessed by a self-administered questionnaire. Results: PC detection was 32% for 6 cores and 40% for 10 cores. Four patients were detected only by median biopsies. Using the binomial distribution table the gain of 4% is statistically significant. There was no statistical difference in morbidity, but a trend towards a higher rate of side effects in the 10-core group. Conclusions: The gain in prostate cancer detection rate by additional median biopsies is low, but statistically significant. There is no difference in morbidity and patient acceptance is high, therefore we favor the 10-core biopsy in our patients.

Author Contacts

PD Dr. med. R. Paul
Department of Urology, Technische Universität Munich
Klinikum rechts der Isar, Ismaninger Strasse 22
DE-81675 Munich (Germany)
Tel. +49 89 4140 2507, Fax +49 89 4140 2585, E-Mail R.Paul@lrz.tu-muenchen.de

Article Information

Received: April 5, 2004
Accepted: September 3, 2004
Number of Print Pages : 6
Number of Figures : 2, Number of Tables : 1, Number of References : 17

Medline Abstract (ID 15812204)

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