A New Parameter in the Detection of Tuberculosis Activity: Reactive Oxygen Metabolites

Vol. 72, No. 2, 2005

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Clinical Investigations

A New Parameter in the Detection of Tuberculosis Activity: Reactive Oxygen Metabolites
Erkan Ceylan^a, Abdullah Gülsün^c, Mehmet Gencer^a, Nurten Aksoy^b

Departments of
^aChest Diseases and
^bBiochemistry, Faculty of Medicine, Harran University, Sanliurfa,
^cDepartment of Chest Diseases, State Hospital of Inegöl, Bursa, Turkey

Address of Corresponding Author

Respiration 2005;72:156-159 (DOI: 10.1159/000084046)

Key Words

Pulmonary tuberculosis
Sequel pulmonary tuberculosis
Detection of activity
Reactive oxygen metabolite

Abstract

Background and Objectives: In countries with a high frequency of tuberculosis, there are problems not only with active lung tuberculosis but also with past lung tuberculosis. Cases with sequel tuberculosis very frequently present with complaints like tuberculosis, and it is very hard to determine whether it is a sequel tuberculosis complication or reactivation of tuberculosis. In this study, we measured the serum reactive oxygen metabolite (ROM) levels of patients with active pulmonary tuberculosis and healthy controls, and investigated if these metabolites can be used as a criterion for differentiation between active pulmonary tuberculosis and sequel pulmonary tuberculosis. Methods: 40 patients with active tuberculosis, 35 patients with sequel pulmonary tuberculosis and 30 healthy control subjects with a similar age range and sex distribution were included in the study. Serum total ROM levels were detected in the patients and control group. Results: Mean serum ROM values were 994 ± 236, 551 ± 135 and 236 ± 59 U/l among active lung tuberculosis cases, sequel lung tuberculosis cases and the healthy control group, respectively. As a result of these findings, serum ROM levels of active lung tuberculosis cases and sequel lung tuberculosis cases were significantly higher than those of the control group (both p < 0.001). The serum ROM levels of active lung tuberculosis cases were also significantly higher than those of sequel lung tuberculosis cases (p < 0.001). Conclusions: In the light of our findings, it may be assumed that serum total ROM values can be used as an activity criterion in the differentiation of active lung tuberculosis and sequel lung tuberculosis.

Author Contacts

Assoc. Prof. Dr. Erkan Ceylan
Yenisehir 8. Sk. Cemalgüllüoglu apt. D:11
TR-63100 Sanliurfa (Turkey)
Tel. +90 414 314 0216, Fax +90 414 315 1181
E-Mail drerkanceylan@yahoo.com

Article Information

Received: January 7, 2004
Accepted after revision: July 8, 2004
Number of Print Pages : 4
Number of Figures : 0, Number of Tables : 3, Number of References : 23

Medline Abstract (ID 15824525)

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