Evaluating Associations between 5-HTTLPR Polymorphism and Alzheimer’s Disease for Korean Patients

Vol. 20, No. 1, 2005

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Original Research Article

Evaluating Associations between 5-HTTLPR Polymorphism and Alzheimer's Disease for Korean Patients
Tae Min Ha^a, Deuk Man Cho^a, Sung Woo Park^b, Myung Jin Joo^c, Bong Ju Lee^a, Bo Geum Kong^{a, b}, Jae Min Kim^d, Jin Sang Yoon^d, Young Hoon Kim^{a, b}

^aDepartment of Neuropsychiatry, School of Medicine, and
^bPaik Institute for Clinical Research, Inje University, Busan,
^cWoosan Medical Foundation, Hyung Ju Hospital, Yangsan, and
^dDepartment of Psychiatry and Research Institute of Medical Science, Chonnam National University Medical School, Kwangju, Republic of Korea

Address of Corresponding Author

Dement Geriatr Cogn Disord 2005;20:31-34 (DOI: 10.1159/000085071)

Key Words

Serotonin transporter
Polymorphism
Alzheimers disease
Delusion
Aggression
Korea

Abstract

There has been growing evidence that the serotonin (5-HT) system is important in the regulation of memory and thus might be associated with Alzheimer's disease (AD), while research results on this issue have been inconsistent. The 5-HT system has also been suggested to be responsible for a significant portion of the behavioural aspects of AD. This study aimed to investigate the associations of the 5-HT transporter gene linked polymorphic region (5-HTTLPR) polymorphism with AD and delusional/aggressive symptoms of AD in Korean samples of 65 patients and 43 controls. The 5-HTTLPR polymorphism was neither associated with AD nor with delusional/aggressive symptoms of AD. It was suggested that phenotypic expression of the 5-HTTLPR polymorphism might be varied according to ethnic differences.

Author Contacts

Prof. Young Hoon Kim
Department of Neuropsychiatry, Inje University, Busan Paik Hospital
633-165 Kaekeum-dong, Busanjin-gu
Busan 614-735 (Republic of Korea)
Tel. +82 51 890 6190, Fax +82 51 894 2532, E-Mail npkyh@chollian.net

Article Information

Accepted: December 8, 2004
Published online: April 12, 2005
Number of Print Pages : 4
Number of Figures : 0, Number of Tables : 3, Number of References : 22

Medline Abstract (ID 15832033)

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