In vitro Activity of Daptomycin versus Linezolid and Vancomycin against Gram-Positive Uropathogens and Ampicillin against Enterococci, Causing Complicated Urinary Tract Infections

Vol. 51, No. 2-3, 2005

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Microbiology

In vitro Activity of Daptomycin versus Linezolid and Vancomycin against Gram-Positive Uropathogens and Ampicillin against Enterococci, Causing Complicated Urinary Tract Infections
Florian M.E. Wagenlehner^a, Norbert Lehn^b, Wolfgang Witte^c, Kurt G. Naber^a

^aDepartment of Urology, St. Elisabeth Hospital, Straubing,
^bInstitute of Clinical Microbiology and Hygiene, University Regensburg, Regensburg, and
^cRobert Koch Institute, Wernigerode, Germany

Address of Corresponding Author

Chemotherapy 2005;51:64-69 (DOI: 10.1159/000085611)

Key Words

Daptomycin
Linezolid
Vancomycin
Ampicillin
Gram-positive uropathogens

Abstract

Objectives: The existing therapeutic options for complicated urinary tract infections (UTI) caused by gram-positive uropathogens are not always optimal. Therefore, newer antimicrobials have to be assessed. Methods: The antimicrobial activity of daptomycin was tested versus linezolid, vancomycin, and ampicillin (enterococci on ly), against pathogens from three different collections: (1) Uropathogens from hospitalized urological patients with complicated and/or hospital-acquired UTIs of the Urologic Clinic, Hospital St. Elisabeth, Straubing. (2) Uropathogens from a multicenter study comprising 37 urological centers throughout Germany. (3) Methicillin-resistant Staphylococcus aureus (MRSA) isolates of patients and staff within the Hospital St. Elisabeth, Straubing. Genotyping of the latter isolates was performed by pulsed-field gel electrophoresis. The minimal inhibitory concentrations (MIC) of daptomycin, linezolid, vancomycin, and ampicillin (only tested against enterococci) were determined by an agar dilution method using a multipointer with an inoculum of 10⁴ CFU per point. Results: For all methicillin-susceptible Staphylococcus aureus (n = 25), MRSA (n = 49), methicillin-susceptible coagulase-negative staphylococci (n = 129), methicillin-resistant coagulase-negative staphylococci (n = 33), for Enterococcus faecalis (n = 289), and for Enterococcus faecium (n = 4) the MICs ranged up to 2 mg/l (daptomycin, linezolid), up to 4 mg/l (vancomycin), and up to 8 mg/l (ampicillin, enterococci only) indicating that all strains were susceptible to the antibiotics tested. Conclusions: According to the in vitro activity daptomycin may be considered a promising antibacterial agent for the treatment of complicated UTI caused by gram-positive uropathogens. Thus, daptomycin should be evaluated in a clinical study

Author Contacts

Kurt G. Naber
Department of Urology, Hospital St. Elisabeth, St. Elisabeth-Strasse 23
DE-94315 Straubing (Germany)
Tel. +49 9421 710 1700, Fax +49 9421 710 1717
E-Mail NaberK@Klinikum-Straubing.de

Article Information

Received: April 12, 2004
Accepted after revision: October 12, 2004
Published online: May 4, 2005
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 7, Number of References : 35

Medline Abstract (ID 15870498)

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