A Possible Antienuretic Effect of Reboxetine in Children and Adolescents with Attention Deficit/Hyperactivity Disorder: Case Series

Vol. 51, No. 4, 2005

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Original Paper

A Possible Antienuretic Effect of Reboxetine in Children and Adolescents with Attention Deficit/Hyperactivity Disorder: Case Series
Paz Toren^{a, b}, Sharon Ratner^a, Nathaniel Laor^{a, b, f}, Dana Lerer-Amisar^c, Abraham Weizman^{b, d, e}

^aTel Aviv-Brull Community Mental Health Center and
^bSackler Faculty of Medicine, Tel Aviv University, Tel Aviv,
^cRambam Medical Center, Haifa, and
^dGeha Mental Health Center and
^eFelsenstein Medical Research Center, Petah Tiqva, Israel;
^fYale Child Study Center, New Haven, Conn., USA

Address of Corresponding Author

Neuropsychobiology 2005;51:239-242 (DOI: 10.1159/000085726)

Key Words

Enuresis
Reboxetine
Norepinephrine
Attention deficit/hyperactivity disorder

Abstract

Reboxetine is a selective norepinephrine reuptake inhibitor. Objectives: To evaluate the antienuretic effect of reboxetine in children with attention deficit and mood disorders. Methods: Six children aged 12-15 years with primary nocturnal enuresis and with attention deficit/hyperactivity disorder with or without other comorbid disorders were treated with reboxetine (4-8 mg/day). Monitoring of enuretic frequency was recorded at baseline and once a week for 6 weeks. Results: A statistically significant decrease in bedwetting was noted along the assessment points (p < 0.001), with the maximal change noted in the first week of treatment (p = 0.004). Reboxetine was well tolerated with minimal and transient side effects. Conclusions: reboxetine may possess an antienuretic effect in some children with the attention deficit/hyperactivity disorder.

Author Contacts

Dr. Paz Toren
7 Geiger Street, Basement Floor
Ramat-Aviv, Tel Aviv 69341 (Israel)
Tel. +972 3 6401802, Fax +972 3 6429136

Article Information

Published online: May 12, 2005
Number of Print Pages : 4
Number of Figures : 0, Number of Tables : 1, Number of References : 33

Medline Abstract (ID 15897675)

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