Neuroendocrine System of the Skin

Vol. 211, No. 3, 2005

Free Abstract Article (Fulltext) Article (PDF 340 KB)

William J. Cunliffe Scientific Awards

Neuroendocrine System of the Skin
Andrzej Slominski

Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tenn., USA

Address of Corresponding Author

Dermatology 2005;211:199-208 (DOI: 10.1159/000087012)

Key Words

Neuroendocrine system, cutaneous
Neuropeptides
Hormones
Neurohormones
Steroids
Secosteroids
Hypothalamic-pituitary-adrenal axis
Serotoninergic/melatoninergic system
Hypothalamic-pituitary-thyroid axis

Abstract

Evidence is accumulating that the skin can serve as a peripheral neuroendocrine organ. The skin neuroendocrine activities are predominantly independent of regulation from the central level (which controls classical hormone secretion) but are rather regulated by local cutaneous factors. These endocrine factors would represent an exquisite regulatory layer addressed at restricting maximally the effect of noxious agents in the skin to preserve local and consequently global homeostasis.

Author Contacts

Andrzej Slominski, MD, PhD
Department of Pathology, Suite 599
University of Tennessee Health Science Center, 930 Madison Avenue
Memphis, TN 38163 (USA)
Tel. +1 901 448 3741, Fax +1 901 448 6979, E-Mail aslominski@utmem.edu

Article Information

Number of Print Pages : 10
Number of Figures : 6, Number of Tables : 0, Number of References : 73

Medline Abstract (ID 16205064)

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