Two Successful Pregnancies after in vitro Fertilization and Embryo Transfer in a Patient with Endometrial Atypical Hyperplasia Bordering on Adenocarcinoma Treated Conservatively with High-Dose Progesterone

Vol. 61, No. 1, 2006

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Case Report

Two Successful Pregnancies after in vitro Fertilization and Embryo Transfer in a Patient with Endometrial Atypical Hyperplasia Bordering on Adenocarcinoma Treated Conservatively with High-Dose Progesterone
Benjamin Piura

Unit of Gynecologic Oncology, Department of Obstetrics and Gynecology, Soroka Medical Center and Faculty of Health Sciences, Cancer Research Center, Ben Gurion University of the Negev, Beer-Sheva, Israel

Address of Corresponding Author

Gynecol Obstet Invest 2006;61:21-23 (DOI: 10.1159/000087916)

Key Words

Endometrial hyperplasia
Endometrial carcinoma
Infertility
Pregnancy
Progesterone
Assisted reproductive technologies

Abstract

Women suffering from anovulatory infertility may develop endometrial hyperplasia and adenocarcinoma due to the unopposed estrogen effect. We present the case of a young infertile woman with endometrial atypical hyperplasia bordering on adenocarcinoma who refused hysterectomy and bilateral salpingo-oophorectomy and achieved two successful pregnancies after conservative treatment with high-dose progesterone followed by in vitro fertilization and embryo transfer. It is concluded that conservative treatment with high-dose progesterone for endometrial hyperplasia and well-differentiated early-stage adenocarcinoma followed by assisted reproductive technologies is an appropriate means for achieving pregnancy. However, the issue of hysterectomy and bilateral salpingo-oophorectomy after delivery or after fertility being no longer required is controversial. If surgery is not performed, close observation with endometrial sampling every 6 months is advisable.

Author Contacts

Prof. Benjamin Piura
Unit of Gynecologic Oncology, Department of Obstetrics and Gynecology
Soroka Medical Center, PO Box 151
Beer-Sheva 84101 (Israel)
Tel. +972 8 6400775, Fax +972 8 6403503, E-Mail piura@bgumail.bgu.ac.il

Article Information

Received: February 7, 2005
Accepted after revision: June 24, 2005
Published online: August 30, 2005
Number of Print Pages : 3
Number of Figures : 0, Number of Tables : 0, Number of References : 9

Medline Abstract (ID 16131806)

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