Is/Are Pattern Recognition Receptor(s) for <i>Staphylococcus aureus</i> Defective in Atopic Dermatitis?

Vol. 212, No. 1, 2006

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Hypotheses and Comments

Is/Are Pattern Recognition Receptor(s) for Staphylococcus aureus Defective in Atopic Dermatitis?
Peck Y. Ong

Division of Clinical Immunology/Allergy, Department of Pediatrics, Childrens Hospital Los Angeles/Keck School of Medicine, University of Southern California, Los Angeles, Calif., USA

Address of Corresponding Author

Dermatology 2006;212:19-22 (DOI: 10.1159/000089016)

Key Words

Atopic dermatitis
Toll-like or pattern recognition receptors
Innate immunity
Defensins

Abstract

It is known that Staphylococcus aureus induces the expression of human beta -defensin-2 (hBD-2), a well-characterized antimicrobial peptide, in keratinocytes. However, in spite of heavy colonization of atopic dermatitis (AD) skin lesions by S. aureus, these lesions have consistently been shown to contain low expression of hBD-2. The current article discusses various possible mechanisms for the low expression of hBD-2 in AD and raises the question whether the innate recognition of S. aureus by keratinocytes in AD is intact.

Author Contacts

Peck Y. Ong, MD
Childrens Hospital Los Angeles
4650 Sunset Blvd., M.S. #75
Los Angeles, CA 90027 (USA)
Tel. +1 323 669 2501, Fax +1 323 666 4627, E-Mail pyong@chla.usc.edu

Article Information

Number of Print Pages : 4
Number of Figures : 0, Number of Tables : 0, Number of References : 45

Medline Abstract (ID 16319468)

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