Reduced Nitric Oxide in Amniotic Fluid of Patients with Chorioamnionitis

Vol. 21, No. 1, 2006

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Paper

Reduced Nitric Oxide in Amniotic Fluid of Patients with Chorioamnionitis
Ghada A. Daoud^a, Yoshikatsu Suzuki^b, Tamao Yamamoto^b, Kaoru Suzumori^b, Hajime Togari^a

Departments of
^aPediatrics and
^bObstetrics and Gynecology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan

Address of Corresponding Author

Fetal Diagn Ther 2006;21:77-80 (DOI: 10.1159/000089053)

Key Words

Infectious abortion
Early second trimester
Cytokines
Immunohistochemistry

Abstract

Objective: Levels of nitric oxide (NO) and cytokines were assessed in amniotic fluid obtained from patients with severe chorioamnionitis (CAM) and appropriate controls. Methods: Amniotic fluid was obtained from 12 patients with CAM (17-24 weeks of gestation) and 89 patients undergoing diagnostic amniocentesis (16-18 weeks of gestation). The concentrations of NO, interleukin-6 (IL-6), and leukocyte elastase (LE) in amniotic fluid were then measured and compared. Results: The concentrations of NO, IL-6, and LE were all higher in CAM cases than in normal pregnant women. Furthermore, an inverse correlation between NO and LE was suggested in the CAM group. Conclusions: These results indicate that in severe CAM, the action of NO might be reduced, not only due to blockage of action but also by degradation, despite increased production.

Author Contacts

Yoshikatsu Suzuki, MD
Department of Obstetrics and Gynecology, Nagoya City University Medical School
Kawasumil, Mizuho-Cho, Mizuho-Ku
Nagoya 467-8601 (Japan)
Tel. +81 52 8538241, Fax +81 52 8422269, E-Mail og.yo@med.nagoya-cu.ac.jp

Article Information

Received: July 13, 2004
Accepted after revision: December 15, 2004
Number of Print Pages : 4
Number of Figures : 3, Number of Tables : 0, Number of References : 19

Medline Abstract (ID 16354981)

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