Address of Corresponding Author

Eur Surg Res 2005;37:274-280 (DOI: 10.1159/000089234)

  Key Words

• Lung transplantation
• Ischemia-reperfusion
• Experimental study
• Animal model

  Abstract

Background: We investigated the effects of neutrophil elastase inhibitor ONO-5046 Na on lung ischemia-reperfusion injury in a canine model of single lung transplantation. Methods: 24 mongrel dogs, 12 donors and 12 recipients, were used for single lung transplantation. Lung grafts were preserved for 18 h by cold ischemia then transplanted into the left thoracic cavity of recipients. In 6 recipients (ONO group), a bolus of ONO-5046 Na (10 mg/kg) was introduced before reperfusion and followed by continuous infusion (10 mg/kg/h). The remaining 6 recipients (control group) did not receive ONO-5046 Na and thus served as controls. We evaluated lung function and respiratory parameters over 240 min. Results: The total cell number in bronchoalveolar lavage fluid increased significantly in the control group in comparison to that in the ONO group. Histologic scores after 4 h of reperfusion and myeloperoxidase activity were significantly lower in the ONO group than in the control group. Conclusion: Neutrophil elastase inhibitor ONO-5046 Na may be useful in ameliorating lung reperfusion injury after transplantation.

Copyright © 2005 S. Karger AG, Basel

  Author Contacts

Tadashi Aoki, MD
Department of Thoracic and Cardiovascular Surgery
Niigata University Graduate School of Medical and Dental Sciences
1-757 Asahimachi, Niigata City 951-8510 (Japan)
Tel. +81 25 227 2243, Fax +81 25 227 0780, E-Mail taoki@med.niigata-u.ac.jp

  Article Information

Received: February 16, 2005
Accepted after revision: September 6, 2005
Number of Print Pages : 7
Number of Figures : 4, Number of Tables : 2, Number of References : 21