Expression of Vascular Adhesion Protein-1 in Atopic Eczema

Vol. 139, No. 2, 2006

Free Abstract Article (Fulltext) Article (PDF 529 KB)

Original Paper

Expression of Vascular Adhesion Protein-1 in Atopic Eczema
Aneta Madej^a, Adam Reich^a, Alina Orda^b, Jacek C. Szepietowski^a

^aDepartment of Dermatology, Venereology and Allergology, and
^bRadioimmunology Laboratory, Department of Cardiology, University of Medicine, Wroclaw, Poland

Address of Corresponding Author

Int Arch Allergy Immunol 2006;139:114-121 (DOI: 10.1159/000090386)

Key Words

Atopic eczema
Adhesion molecules
Inflammation
Leukocytes
Vascular adhesion protein-1

Abstract

Background:Vascular adhesion protein-1 (VAP-1) is an adhesion molecule with an enzymatic activity which partakes in the migration process of lymphocytes. The aim of this study was to investigate VAP-1 expression in atopic eczema (AE) in comparison with healthy controls and psoriatic individuals. Material and Methods:Forty adult patients suffering from AE aged between 18 and 56 years were included in the study. The control group consisted of 35 healthy volunteers aged between 19 and 49 years and of 71 psoriatic patients aged between 23 and 89 years. The serum concentration of soluble VAP-1 (sVAP-1) was evaluated by ELISA and VAP-1 expression in the skin by immunohistochemistry. Results: Serum level of sVAP-1 in AE patients before treatment was significantly higher compared with healthy volunteers. Similarly, a higher mean number of VAP-1-positive vessels was found in both lesional and nonlesional atopic skin compared with healthy skin. Treatment of AE resulted in a significant reduction in the serum level of sVAP-1. On the other hand, both the serum level of sVAP-1 and the number of dermal vessels with expression of VAP-1 were significantly lower in AE patients compared with psoriatic individuals. Conclusion: This study indicates the important role of VAP-1 in the pathogenesis of chronic inflammatory cutaneous disorders, including AE.

Author Contacts

Correspondence to: Adam Reich, MD
Department of Dermatology, Venereology and Allergology, University of Medicine Ul. Chalubinskiego 1
PL-50-368 Wroc lstrok aw (Poland)
Tel. +48 71 7842288, Fax +48 71 3270942, E-Mail adi_medicalis@go2.pl

Article Information

Received: May 24, 2005
Accepted after revision: September 14, 2005
Published online: December 19, 2005
Number of Print Pages : 8
Number of Figures : 5, Number of Tables : 1, Number of References : 33

Medline Abstract (ID 16361866)

Download Citation

Cited In

This journal is part of the fourth subject package of the Karger

Journal Archive Collection

Information on packages (PDF)
Free sample issues

For non-native English speakers and international authors who would like assistance with their writing before submission, we suggest American Journal Experts for their scientific editing service.